Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Aug 1;166(2):613-8.
doi: 10.1084/jem.166.2.613.

Species heterogeneity in macrophage expression of the CD4 antigen

P R Crocker, W A Jefferies, S J Clark, L P Chung, S Gordon

Species heterogeneity in macrophage expression of the CD4 antigen

P R Crocker et al. J Exp Med. .

Abstract

The CD4 antigen is expressed on T cells of all mammalian species examined and appears to play an important role in the response of T cells to antigen. In humans, the molecule acts as a receptor for the AIDS virus. Previous studies have demonstrated that M phi in the rat and human also express the CD4 antigen, which is indistinguishable from that on T cells. In this paper we demonstrate by FACS analysis, Northern blot hybridization, and immunoperoxidase labeling that, in striking contrast to the rat and human, mouse M phi do not express the CD4 (L3T4) antigen. This species heterogeneity indicates that T cells and M phi regulate CD4 antigen expression independently and that CD4 may not be essential for M phi function.

PubMed Disclaimer

References

    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1649-53 - PubMed
    1. J Immunol. 1983 Nov;131(5):2445-51 - PubMed
    1. J Immunol. 1984 Jun;132(6):2775-82 - PubMed
    1. J Exp Med. 1985 Jul 1;162(1):117-27 - PubMed

Publication types

Substances