Evolution of neuronal identity in the cerebral cortex

Abstract

To understand neocortex evolution, we must define a theory for the elaboration of cell types, circuits, and architectonics from an ancestral structure that is consistent with developmental, molecular, and genetic data. To this end, cross-species comparison of cortical cell types emerges as a very informative approach. We review recent results that illustrate the contribution of molecular and transcriptomic data to the construction of plausible models of cortical cell-type evolution.