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. 2019 Nov;20(8):684-689.
doi: 10.1038/s41435-019-0077-9. Epub 2019 May 20.

Relationship between human leukocyte antigen alleles and risk of Kaposi's sarcoma in Cameroon

Elena M Cornejo Castro  1 , Brian J Morrison  1 , Vickie A Marshall  1 , Nazzarena Labo  1 , Wendell J Miley  1 , Nathan Clements  1 , George Nelson  2   3 , Paul Ndom  4 , Kristen Stolka  5 , Jennifer J Hemingway-Foday  5 , Mahamat Abassora  4 , Xiaojiang Gao  6 , Jennifer S Smith  7 , Mary Carrington  6   8 , Denise Whitby  9
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Relationship between human leukocyte antigen alleles and risk of Kaposi's sarcoma in Cameroon

Elena M Cornejo Castro et al. Genes Immun. 2019 Nov.

Abstract

Several studies published to date report associations between human leukocyte antigen (HLA) alleles and different types of Kaposi's Sarcoma (KS). However, there is little concordance between the HLA alleles identified and the populations studied. To test whether HLA alleles associate with KS in a Cameroonian case-control study, we performed high-resolution HLA typing in KSHV seropositive individuals. Among HIV-positive individuals, carriers of HLA-B*14:01 were at a significantly higher risk of AIDS-KS (p = 0.033). For HIV-negative patients, a gene-wise comparison of allele frequencies identified the HLA-B (p = 0.008) and -DQA1 (p = 0.002) loci as possible risk factors for endemic KS. Our study provides additional understanding of genetic determinants of KS and their implications in disease pathogenesis. Further validation of these findings is needed to define the functional relevance of these associations.

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Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic representation of KSHV-positive, HIV-positive, and HIV-negative cohorts. a Welch Two Sample t-test; b Pearson’s Chi-squared test. IQR interquartile range
See this image and copyright information in PMC

References

    1. Goncalves PH, Uldrick TS, Yarchoan R. HIV-associated Kaposi sarcoma and related diseases. AIDS. 2017;31:1903–16. - PMC - PubMed
    1. Krown SE. AIDS-associated Kaposi’s sarcoma: pathogenesis, clinical course and treatment. AIDS. 1988;2:71–80. - PubMed
    1. Hutt MS, Burkitt D. Geographical distribution of cancer in East Africa: a new clinicopathological approach. Br Med J. 1965;2:719–22. - PMC - PubMed
    1. Mbulaiteye SM, Katabira ET, Wabinga H, Parkin DM, Virgo P, Ochai R, et al. Spectrum of cancers among HIV-infected persons in Africa: the Uganda AIDS-Cancer Registry Match Study. Int J Cancer J Int du Cancer. 2006;118:985–90. - PubMed
    1. Cook PM, Whitby D, Calabro ML, Luppi M, Kakoola DN, Hjalgrim H, et al. Variability and evolution of Kaposi’s sarcomaassociated herpesvirus in Europe and Africa. International Collaborative Group. AIDS. 1999;13:1165–76. - PubMed

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