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Review
. 2019 Jun;7(6):e744.
doi: 10.1002/mgg3.744. Epub 2019 May 20.

Genetics and genomic medicine in Sri Lanka

Affiliations
Review

Genetics and genomic medicine in Sri Lanka

Nirmala D Sirisena et al. Mol Genet Genomic Med. 2019 Jun.

Abstract

The completion of the Human Genome Project in 2003 heralded in a new era marked by remarkable advances in biomedical research leading to the establishment of genomics-based translational medicine mainly in the developed world. However, the development of such advances has been hampered in most parts of the developing world due to scarcity of resources and trained personnel. Genetics and genomic medicine are currently in the process of being integrated into the Sri Lankan health care system. These developments have taken place mainly due to the heightened awareness and increasing demands made by the public for provision of genetic diagnostic and therapeutic services in clinical care. Due to the exorbitant costs incurred in the maintenance of these services and the dearth of adequately trained manpower, only a few centers in the country, mainly in Universities or private sector, are currently engaged in providing these services to the public. This article aims to provide an overview of the genetics and genomic medicine services in Sri Lanka from its early developments to the current state.

Keywords: clinical genetics; genetic testing; genomic medicine; genomics; medical genetics.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Political map of Sri Lanka (Adapted from Encyclopaedia Britannica—Peiris, 2019)
Figure 2
Figure 2
Age structure of the Sri Lankan population (2016) (Adapted from Encyclopaedia Britannica—Peiris, 2019)
Figure 3
Figure 3
Distribution of genetic diagnostic centers in Sri Lanka

References

    1. Chan, S. L. , Samaranayake, N. , Ross, C. J. D. , Toh, M. T. , Carleton, B. , Hayden, M. R. , … Brunham, L. R. (2016). Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: Implications for clinical implementation of pharmacogenomics. Pharmacogenetics and Genomics, 26, 28–39. 10.1097/FPC.0000000000000182 - DOI - PMC - PubMed
    1. Corea, S. M. X. (2019). Epidemiology of congenital malformations in Sri Lanka. [Thesis for MD (Community Medicine, 1982)]. Sri Lanka: Post Graduate Institute of Medicine (PGIM), University of Colombo; Vol. 127 (Doctoral dissertation). Retrieved from https://www.librepository.pgim.cmb.ac.lk/handle/1/1120
    1. Corner, G. W. (2019). First International Conference on Congenital Malformations—papers and discussions presented at the First International Conference on Congenital Malformations, London, England, July 18–22, 1960. Retrieved from https://www.infolanka.com/org/genetics/essays/essayv1.htm
    1. De Silva, C. C. (1957). Abnormal haemoglobins and haemoglobinopathies. Journal of Lady Ridgeway Hospital for Children, Colombo, 6(1), 16–32.
    1. De Silva, D. (2004). Genetic disorders and medical genetics in Sri Lanka In Kumar D. (Ed.), Genetic disorders of the Indian Subcontinent (pp. 519–540). Dordrecht, the Netherlands: Kluwer Academic Press.

MeSH terms