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. 2019 May 20;8(1):122.
doi: 10.1186/s13643-019-1037-1.

Epidemiology of respiratory viral infections in people with acute respiratory tract infections in Africa: the VARIAFRICA systematic review and meta-analysis protocol

Sebastien Kenmoe  1 , Jean Joel Bigna  2   3 , Abdou Fatawou Modiyinji  1   4 , Fredy Brice N Simo  1   5 , Richard Njouom  6
Affiliations

Epidemiology of respiratory viral infections in people with acute respiratory tract infections in Africa: the VARIAFRICA systematic review and meta-analysis protocol

Sebastien Kenmoe et al. Syst Rev. .

Abstract

Introduction: Better characterisation of the epidemiological data on respiratory viral infections among people with acute respiratory tract infection (ARTI) can help to implement efficient strategies to curb the burden of ARTI in Africa. We will conduct a systematic review and meta-analysis to determine the prevalence and factors associated with respiratory viral infection in people of all ages with ARTI residing in Africa.

Methods: This work will include cross-sectional studies published between January 1, 2000 and December 31, 2017, without any language restriction, on populations residing in African countries. We will consider studies that reported the prevalence of respiratory viruses in people with ARTI confirmed by a polymerase chain reaction technique. We will be searching PubMed, Embase, African Journals Online, Web of Science, and Global Index Medicus. The selection of relevant studies, extraction of data, and evaluation of the quality of the articles will be carried out independently by two review authors, and the discrepancies will be resolved by consensus or intervention of a third author. The heterogeneity of the studies will be assessed using the χ2 test on Cochrane's Q statistic. Publication bias will be assessed by the Egger test. Studies will be pooled using a random-effect meta-analysis model. Results will be presented by age group and sub-region of Africa. Using meta-regression models, we will identify factors associated with viral infections in people with ARTI.

Discussion: This systematic review and meta-analysis is based on published data and therefore does not require ethical approval. This work will serve as a basis for the development of strategies for prevention and control ARTI in Africa and will also serve to identify data gaps and guide future investigations. The final report will be published in peer-reviewed journals as a scientific article and presented in workshops, conferences, and scientific conferences.

Systematic review registration: PROSPERO, CRD42018088261 .

Keywords: Acute respiratory tract infections; Africa; Epidemiology; Respiratory viruses.

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Conflict of interest statement

The authors declare that they have no competing interests.

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References

    1. Troeger C, Forouzanfar M, Rao PC, et al. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the global burden of disease study 2015. Lancet Infect Dis. 2017;17:1133–1161. doi: 10.1016/S1473-3099(17)30396-1. - DOI - PMC - PubMed
    1. Ruuskanen O, Lahti E, Jennings LC, et al. Viral pneumonia. Lancet Lond Engl. 2011;377:1264–1275. doi: 10.1016/S0140-6736(10)61459-6. - DOI - PMC - PubMed
    1. Sanou AM, Cissé A, Millogo T, et al. Systematic review of articles on etiologies of acute respiratory infections in children aged less than five years in sub-Saharan Africa, 2000-2015. EC Microbiol. 2016;3:556–571.
    1. Centers for reviews and dissemination . CRD’s guidance for undertaking reviews in healthcare: centers for reviews and dissemination. 2009.
    1. Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4. 10.1186/2046-4053-4-1. - PMC - PubMed