Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Aug;123(2):e159-e160.
doi: 10.1016/j.bja.2019.04.047. Epub 2019 May 17.

Propofol pharmacokinetic model and lean body weight scalar for dose estimation in morbid obesity

John H P Friesen  1
Affiliations
Comment

Propofol pharmacokinetic model and lean body weight scalar for dose estimation in morbid obesity

John H P Friesen. Br J Anaesth. 2019 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares that they have no conflict of interest.

Figures

Figure 1
Fig. 1
The ‘Eleveld model’ graph plots total propofol induction doses for 50% effect for patients with BMI from 30 to 50 kg m−2 (data from Figure 7 in Eleveld and colleagues study) and BMI of 22 kg m−2 (dose of 1.97 mg kg−1 from Figure 5 in Eleveld and colleagues study). The ‘per kg LBW’ graph plots doses calculated as 1.97 mg kg−1 of lean body weight (Janmahasatian and colleagues lean body weight formula). All values represent female subjects of height 170 cm and age 35 yr. Nominal non-obese BMI is 22 kg m−2.
See this image and copyright information in PMC

Comment on

References

    1. Nightingale C.E., Cousins J.M., Fox W.T.F., Kennedy N.J., Margarson M.P., Shearer E. Response to NAP5 from the society for obesity and bariatric anaesthesia SOBA. Br J Anaesth. 2015;115:140–141. - PubMed
    1. Pandit J.J., Cook T.M. Appropriate dosing of lipid-soluble anaesthetics in obese patients: NAP5 recommendations. Br J Anaesth. 2015;115:141–142. - PubMed
    1. Eleveld D.J., Colin P., Absalom A.R., Struys M.M.R.F. Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation. Br J Anaesth. 2018;120:942–959. - PubMed
    1. Janmahasatian S., Duffull S.B., Ash S., Ward L.C., Byrne N.M., Green B. Quantification of lean bodyweight. Clin Pharmacokinet. 2005;44:1051–1065. - PubMed
    1. Friesen J.H.P. Propofol induction: normalizing the dose in morbidly obese patients. Can J Anesth. 2017;64:456–460. - PubMed