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Published Erratum
. 2019 May 28;116(22):11075-11076.
doi: 10.1073/pnas.1907056116. Epub 2019 May 20.

Correction for Davenport et al., Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

No authors listed
Published Erratum

Correction for Davenport et al., Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

No authors listed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 3.
Fig. 3.
Proximal signaling dissipates more quickly in carCTL than in tcrCTL. (A) RPPA analysis of CAR.OTI CTL signaling at 2 min and 30 min after plate-bound TCR or CAR stimulation. The 43 proteins included in the heat map all have statistically significant changes at 30 min. Blue and yellow represent down- and up-regulation, respectively. Relative protein levels (Z-scores) are shown in the heat map, color-coded according to the legend. Columns are scaled to have a mean of 0 and an SD of 1. (B) Quantitated graphical analysis from A of select proteins involved in T cell signaling, cell survival, or membrane trafficking. Protein level changes were assessed using the Empirical Bayes moderated-t statistic where *P < 0.05, **P < 0.01, ***P < 0.001. (C) Western blot validation of pErk expression from B. Western blot analysis probing for pErk at 2 min, 10 min, and 30 min of CAR.OTI stimulation with solid-phase anti-CD3/CD28 (TCR) or anti-tag (CAR). The pERK level was normalized to total amount of protein and represented as fold difference to TCR expression at each time point. Data is from a single experiment representative of two.
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