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. 2019 May 21;321(19):1933-1934.
doi: 10.1001/jama.2019.3076.

Trends in Incidence and Stage at Diagnosis of Colorectal Cancer in Adults Aged 40 Through 49 Years, 1975-2015

Reinier G S Meester  1 , Ajitha Mannalithara  1 , Iris Lansdorp-Vogelaar  2 , Uri Ladabaum  1
Affiliations

Trends in Incidence and Stage at Diagnosis of Colorectal Cancer in Adults Aged 40 Through 49 Years, 1975-2015

Reinier G S Meester et al. JAMA. .

Abstract

This cancer epidemiology study uses SEER program data to describe trends in stage of incident colorectal cancer in adults aged 40-49 years between 1975 and 2015 to understand if apparent increases in incidence are due to earlier detection or true increases in risk.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Meester reported receiving grant support from the Netherlands Organisation for Scientific Research. Dr Lansdorp-Vogelaar reported receiving grants from National Cancer Institute, European Commission, ZonMw, the Netherlands Institute of Public Health, the National Cancer Institute, and the Dutch Cancer Society. Dr Ladabaum reported receiving personal fees from Covidien, Motus GI, Clinical Genomics, Universal Dx, and Quorum and grants and personal fees from Exact Sciences. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Trends in Colorectal Cancer (CRC) Incidence by Stage in Adults Aged 40 Through 49 Years
Data are from the Surveillance, Epidemiology, and End Results program and were age-standardized to the 2000 US standard population. Solid lines represent fitted piecewise–log linear trends. Average annual percentage changes (AAPCs) with parametric confidence intervals were calculated from 1995, when incidence started to increase. aStatistically significantly different from zero at 95% significance thresholds.
Figure 2.
Figure 2.. Shift in Stage Distribution of Colorectal Cancers (CRCs) Diagnosed in Adults Aged 40 Through 49 Yearsa
aData are from the Surveillance, Epidemiology, and End Results program. 95% Confidence intervals were derived using the Sison-Glaz method for multinomial data. Statistical tests (2-sided Pearson χ2) assessed the stage-specific changes in proportions from 1990-1994 to 2011-2015. The differential relative increase by stage in the overall stage distribution was P<.001. Error bars indicate 95% CIs.
See this image and copyright information in PMC

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