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. 2019 Jul 1;76(7):671-672.
doi: 10.1001/jamapsychiatry.2019.0740.

Targeting Cognition and Networks Through Neural Oscillations: Next-Generation Clinical Brain Stimulation

Alik S Widge  1 , Earl K Miller  2
Affiliations

Targeting Cognition and Networks Through Neural Oscillations: Next-Generation Clinical Brain Stimulation

Alik S Widge et al. JAMA Psychiatry. .
No abstract available

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Widge reported receiving grants from the National Institutes of Health during the conduct of the study, receiving personal fees and nonfinancial support from Medtronic outside the submitted work, and having patents pending for applications of deep brain stimulation and neural oscillations and for applications of neural oscillations for cognitive remediation. Dr Miller reported having patents pending in applications of neural oscillations for cognitive remediation.

Figures

Figure.
Figure.. Levels of Specificity and Methods for Enhancing the Specificity of Neurostimulation
A, Conceptual diagram of neuromodulation specificity levels and methods/concepts for implementation. Personal specificity involves delivering neuromodulation to the appropriate patients: those with a specific diagnosis, level of severity, or phenotype (eg, the exclusion of patients with rapid-cycling bipolar disorder from trials in which mania is a risk). Spatial specificity refines brain targets within an individual, moving beyond average stereotactic coordinates to a precise application of energy to key brain structures. Temporal specificity extends this application to stimulate targets only at key moments, such as times when symptoms are high or when neural activity is especially vulnerable to change. B, Conceptual diagram of oscillation-locked stimulation, one variant of temporal specificity. A neural oscillation shows peaks and troughs (phases) at a defined frequency. Advanced modeling may permit stimulation pulses to be delivered only at specific phases of the oscillation, acting in tune with changes in tissue excitability.
See this image and copyright information in PMC

References

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