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Comment
. 2019 May 21;50(5):1129-1131.
doi: 10.1016/j.immuni.2019.04.016.

Putting the K+ in K+aloric Restriction

Evan C Lien  1 , Allison N Lau  2 , Matthew G Vander Heiden  3
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Free article
Comment

Putting the K+ in K+aloric Restriction

Evan C Lien et al. Immunity. .
Free article

Abstract

Metabolic changes affect T lymphocyte function, and understanding this phenomenon could improve immunotherapy. In a recent paper in Science, Vodnala et al. (2019) report that tumor microenvironmental potassium impairs T cell nutrient uptake and thus causes functional caloric restriction and allows improved anti-tumor immune responses.

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  • T cell stemness and dysfunction in tumors are triggered by a common mechanism.
    Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP. Vodnala SK, et al. Science. 2019 Mar 29;363(6434):eaau0135. doi: 10.1126/science.aau0135. Science. 2019. PMID: 30923193 Free PMC article.

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