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Review
. 2019 Aug 15;58(16):2387-2391.
doi: 10.2169/internalmedicine.1662-18. Epub 2019 May 22.

Acute Promyelocytic Leukemia and HIV: Case Reports and a Review of the Literature

Akane Kunitomi  1 , Yuta Hasegawa  1 , Junji Lmamura  2 , Yoshiyuki Yokomaku  2 , Takashi Tokunaga  1 , Yasuhiko Miyata  1 , Hiroatsu Iida  1 , Hirokazu Nagai  1
Affiliations
Review

Acute Promyelocytic Leukemia and HIV: Case Reports and a Review of the Literature

Akane Kunitomi et al. Intern Med. .

Abstract

Acute promyelocytic leukemia (APL) in human immunodeficiency virus (HIV)-infected individuals is very rare. There is currently no consensus regarding the use of anti-cancer drugs with highly active anti-retroviral therapy (ART) in these patients due to their small number. We herein report two cases of APL with HIV-infected patients. Both cases received all-trans-retinoic acid-containing chemotherapies and achieved complete remission. ART was continued throughout the treatment course. The clinical course of these cases suggests that it is preferable to perform standard chemotherapy for APL with ART if patients have an adequate performance status.

Keywords: acute promyelocytic leukemia; human immunodeficiency virus.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure.
Figure.
Clinical courses of patients 1 (A) and 2 (B). ATRA: all-trans-retinoic acid, G-CSF: granulocyte-colony-stimulating factor, WBC: white blood cell, Ara-C: cytarabine, IDA: idarubicin, MTZ: mitoxantrone, DEX: dexamethasone, CFPM: cefepime, MEPM: meropenem, VCM: vancomycin, CRP: C-reactive protein, FN: febrile neutropenia, PSL: prednisone, TAZ/PIPC: tazobactam/piperacillin
See this image and copyright information in PMC

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