Case Reports
doi: 10.1136/adc.54.1.76.
Chloramphenicol and phenobarbitone--a drug interaction
- PMID: 311186
- PMCID: PMC1545200
- DOI: 10.1136/adc.54.1.76
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Case Reports
Chloramphenicol and phenobarbitone--a drug interaction
Arch Dis Child.
1979 Jan.
Abstract
Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.
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