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Case Reports
. 1979 Jan;54(1):76-7.
doi: 10.1136/adc.54.1.76.

Chloramphenicol and phenobarbitone--a drug interaction

R A Bloxham, G M Durbin, T Johnson, M H Winterborn
Case Reports

Chloramphenicol and phenobarbitone--a drug interaction

R A Bloxham et al. Arch Dis Child. 1979 Jan.

Abstract

Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.

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References

    1. J Pediatr. 1978 Feb;92(2):235-6 - PubMed
    1. Pharmacol Rev. 1967 Sep;19(3):317-66 - PubMed
    1. Antimicrob Agents Chemother. 1976 Jun;9(6):874-8 - PubMed
    1. Biochem Pharmacol. 1968 Dec;17(12):2381-90 - PubMed

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