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. 2019 Apr 29:12:277-283.
doi: 10.2147/CCID.S198081. eCollection 2019.

Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness

Mohammed G Turkmani  1 , Koenraad De Boulle  2 , Wolfgang G Philipp-Dormston  3
Affiliations

Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness

Mohammed G Turkmani et al. Clin Cosmet Investig Dermatol. .

Abstract

Background: Delayed reactions after facial hyaluronic acid injection are relatively rare complications. Their cause may be infectious or immune-mediated in origin, and their outbreak can be triggered, for example, by an influenza-like illness. Objective: To describe potential adverse event of influenza like illness following dermal filler injection. Methods: We report fourteen unusual cases of delayed hypersensitivity reaction to several brands of hyaluronic acid dermal filler following influenza like illness. Results: Increasing evidence implicates influenza infection in the pathogenesis of late onset filler reaction. Conclusion: Although there is a low risk of late onset adverse reaction with hyaluronic acid fillers, injecting physicians must be aware of the possible filler reaction following the influenza infection.

Keywords: complications; fillers; hyaluronic acid; hypersensitivity; infection; influenza; reaction.

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Conflict of interest statement

Wolfgang G Philipp-Dormston reports being a clinical trial investigator, scientific advisor, and/or speaker for Allergan, Galderma, and Merz, and no other conflicts of interest or payments for this publication. The other authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Sites of reaction.
Figure 2
Figure 2
Patient 1 and patient 2: sites of reaction before (left) and two weeks after (right) treatment.
See this image and copyright information in PMC

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