Metformin in tuberculosis: beyond control of hyperglycemia

doi:10.1007/s15010-019-01322-5

Review

. 2019 Oct;47(5):697-702.

doi: 10.1007/s15010-019-01322-5. Epub 2019 May 22.

Metformin in tuberculosis: beyond control of hyperglycemia

William Oglesby¹, Ali M Kara¹, Hector Granados², Jorge L Cervantes³

Affiliations

¹ Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, 5001 El Paso Dr., El Paso, TX, 79905, USA.
² Department of Pediatrics, Texas Tech University Health Sciences Center, El Paso, El Paso, TX, 79905, USA.
³ Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, 5001 El Paso Dr., El Paso, TX, 79905, USA. jorge.cervantes@ttuhsc.edu.

PMID: 31119504
DOI: 10.1007/s15010-019-01322-5

Review

Metformin in tuberculosis: beyond control of hyperglycemia

William Oglesby et al. Infection. 2019 Oct.

. 2019 Oct;47(5):697-702.

doi: 10.1007/s15010-019-01322-5. Epub 2019 May 22.

Authors

William Oglesby¹, Ali M Kara¹, Hector Granados², Jorge L Cervantes³

Affiliations

¹ Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, 5001 El Paso Dr., El Paso, TX, 79905, USA.
² Department of Pediatrics, Texas Tech University Health Sciences Center, El Paso, El Paso, TX, 79905, USA.
³ Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, 5001 El Paso Dr., El Paso, TX, 79905, USA. jorge.cervantes@ttuhsc.edu.

PMID: 31119504
DOI: 10.1007/s15010-019-01322-5

Abstract

Two global epidemics, diabetes mellitus (DM) and tuberculosis (TB), have converged making their control even more challenging. We herein have reviewed metformin's (MTF) effect on patients with active and latent TB, as well as discussed its newly discovered biological mechanisms in mycobacteria. Mounting evidence suggests that MTF provides better outcomes in TB patients, especially those with DM. The mechanisms by which MTF produces its benefits are multiple. Though metformin's potential has been proven in patients with DM, larger and more thorough clinical trials, in DM and non-DM-TB patients, need to be conducted. MTF could be added to the arsenal of anti-TB drugs, aiding in the goal of TB eradication worldwide.

Keywords: Anti-tuberculous therapy; Diabetes; Metformin; Tuberculosis.

PubMed Disclaimer

Cited by

Metformin improves Mycobacterium avium infection by strengthening macrophage antimicrobial functions.
Mediaas SD, Haug M, Louet C, Wahl SGF, Gidon A, Flo TH. Mediaas SD, et al. Front Immunol. 2024 Dec 16;15:1463224. doi: 10.3389/fimmu.2024.1463224. eCollection 2024. Front Immunol. 2024. PMID: 39737195 Free PMC article.
Treatment course of cavitary pulmonary tuberculosis combined with tuberculosis in a parotid Warthin's tumor: a case report and literature review.
Hu SS, Wei QC, Wu Y, Li XN, Liu FJ, Wang B. Hu SS, et al. BMC Infect Dis. 2024 Nov 14;24(1):1298. doi: 10.1186/s12879-024-10193-7. BMC Infect Dis. 2024. PMID: 39543494 Free PMC article. Review.
Anti-diabetics and antimicrobials: Harmony of mutual interplay.
Hegazy WAH, Rajab AAH, Abu Lila AS, Abbas HA. Hegazy WAH, et al. World J Diabetes. 2021 Nov 15;12(11):1832-1855. doi: 10.4239/wjd.v12.i11.1832. World J Diabetes. 2021. PMID: 34888011 Free PMC article. Review.
The Presence of Bacteriophages in the Human Body: Good, Bad or Neutral?
Łusiak-Szelachowska M, Weber-Dąbrowska B, Żaczek M, Borysowski J, Górski A. Łusiak-Szelachowska M, et al. Microorganisms. 2020 Dec 16;8(12):2012. doi: 10.3390/microorganisms8122012. Microorganisms. 2020. PMID: 33339331 Free PMC article. Review.
Metformin promotes smear conversion in tuberculosis-diabetes comorbidity and construction of prediction models.
Wang Y, Zhou Y, Chen L, Cheng Y, Lai H, Lyu M, Zeng J, Zhang Y, Feng P, Ying B. Wang Y, et al. J Clin Lab Anal. 2022 Dec;36(12):e24755. doi: 10.1002/jcla.24755. Epub 2022 Nov 8. J Clin Lab Anal. 2022. PMID: 36347820 Free PMC article.

See all "Cited by" articles

References

1. Houben RM, Dodd PJ. The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med. 2016;13:e1002152. - DOI
1. World Health Organization W. Global tuberculosis report. 2018. ISBN 978-92-4-156564-6
1. Ruslami R, Aarnoutse RE, Alisjahbana B, van der Ven AJ, van Crevel R. Implications of the global increase of diabetes for tuberculosis control and patient care. Trop Med Int Health TM & IH. 2010;15:1289–99. - DOI
1. Jeon CY, Harries AD, Baker MA, Hart JE, Kapur A, Lonnroth K, et al. Bi-directional screening for tuberculosis and diabetes: a systematic review. Trop Med Int Health TM & IH. 2010;15:1300–14. - DOI
1. Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, Lonnroth K, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med. 2011;9:81. - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Houben RM, Dodd PJ. The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med. 2016;13:e1002152. - DOI

[2] Houben RM, Dodd PJ. The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med. 2016;13:e1002152. - DOI

[3] World Health Organization W. Global tuberculosis report. 2018. ISBN 978-92-4-156564-6

[4] World Health Organization W. Global tuberculosis report. 2018. ISBN 978-92-4-156564-6

[5] Ruslami R, Aarnoutse RE, Alisjahbana B, van der Ven AJ, van Crevel R. Implications of the global increase of diabetes for tuberculosis control and patient care. Trop Med Int Health TM & IH. 2010;15:1289–99. - DOI

[6] Ruslami R, Aarnoutse RE, Alisjahbana B, van der Ven AJ, van Crevel R. Implications of the global increase of diabetes for tuberculosis control and patient care. Trop Med Int Health TM & IH. 2010;15:1289–99. - DOI

[7] Jeon CY, Harries AD, Baker MA, Hart JE, Kapur A, Lonnroth K, et al. Bi-directional screening for tuberculosis and diabetes: a systematic review. Trop Med Int Health TM & IH. 2010;15:1300–14. - DOI

[8] Jeon CY, Harries AD, Baker MA, Hart JE, Kapur A, Lonnroth K, et al. Bi-directional screening for tuberculosis and diabetes: a systematic review. Trop Med Int Health TM & IH. 2010;15:1300–14. - DOI

[9] Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, Lonnroth K, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med. 2011;9:81. - DOI

[10] Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, Lonnroth K, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med. 2011;9:81. - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Metformin in tuberculosis: beyond control of hyperglycemia

Affiliations

Metformin in tuberculosis: beyond control of hyperglycemia

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous