Promoting effect of 12-O-tetradecanoylphorbol-13-acetate on neurogenic microtumors initiated by transplacental exposure to N-ethyl-N-nitrosourea
- PMID: 3112067
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Promoting effect of 12-O-tetradecanoylphorbol-13-acetate on neurogenic microtumors initiated by transplacental exposure to N-ethyl-N-nitrosourea
Jpn J Cancer Res.
1987 Jun.
Abstract
The promoting effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the occurrence of neurogenic microtumors in SD-JCL rats initiated transplacentally with N-ethyl-N-nitrosourea (ENU) was investigated. The treatment with TPA induced earlier occurrence of microtumors than as compared with the initiation alone. Thus, TPA has tumor-promoting activity on the formation of neurogenic microtumors in rats prenatally exposed to ENU.
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