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Review
. 2019 May 13;181(20):V12180849.

[Preimplantation genetic testing for aneuploidy]

[Article in Danish]
Viktoria Holmqvist  1 , Laura Kristine Soenderberg Roos, Kristin Ros Kjartansdottir, Morten Dunø, Morten Rønn Petersen, Christina Hnida, Inge Søkilde Pedersen, Anja Ernst, Christian Liebst Frisk Toft, Tue Diemer, Hans Jakob Ingerslev, Anja Pinborg, Kristine Løssl
Affiliations
  • PMID: 31124451
Free article
Review

[Preimplantation genetic testing for aneuploidy]

[Article in Danish]
Viktoria Holmqvist et al. Ugeskr Laeger. .
Free article

Abstract

This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a reduced LBR. Today, PGT-A includes comprehensive chromosome screening primarily of blastocyst biopsies. The benefit of PGT-A is highly debated: some suggest improved treatment outcome, while others claim, that the procedure is not cost-effective.

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