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Review
. 2019 May 23;90(2):327-330.
doi: 10.23750/abm.v90i2.8218.

Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature

Carlotta Mutti  1 , Erica Curti, Rosario Ciliento, Andrea Melpignano, Irene Florindo, Lucia Zinno, Enrico Sasso, Liborio Parrino, Giovanni Pavesi, Anna Elisabetta Vaudano
Affiliations
Review

Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature

Carlotta Mutti et al. Acta Biomed. .

Abstract

Herpes simplex virus encephalitis (HSE) is the most common cause of letal encephalitis and its prevalence appears higher among oncologic patients who undergo brain radiotherapy (RT). We describe a case of 76-year-old woman with glioblastoma multiforme (GBM) who developed HSE shortly after brain RT. Cerebrospinal fluid analysis (CSF) was normal and the diagnosis was driven by brain MRI and EEG. Prompt introduction of antiviral therapy improved the clinical picture. We highlight the importance of EEG and brain MRI for the diagnosis and suggest the possibility of antiviral profilaxys in oncologic patients who undergo brain RT.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

Figures

Figure 1.
Figure 1.
EEG: 0.5-0.75 Hz lateralized periodic discharges (LPD) in left temporal region, sensitivity 70 μV
Figure 2.
Figure 2.
3T Brain MRI: Axial FLAIR sequence, hyperintensity of left temporo-polar and mesio-temporal lobe. R: right; L: left
See this image and copyright information in PMC

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