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. 2019 May 24;16(5):e1002814.
doi: 10.1371/journal.pmed.1002814. eCollection 2019 May.

Predicting progression to active tuberculosis: A rate-limiting step on the path to elimination

Affiliations

Predicting progression to active tuberculosis: A rate-limiting step on the path to elimination

Ajit Lalvani et al. PLoS Med. .

Abstract

In a Perspective, Ajit Lalvani and colleagues discuss new approaches to predicting progression to active tuberculosis.

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Conflict of interest statement

I have read the journal's policy and the authors of this manuscript have the following competing interests: AL is named inventor on patents pertaining to T-cell-based diagnosis, including current and second-generation IGRA technologies and flow-cytometric diagnosis and prognosis of tuberculosis infection and disease. Some of these patents were assigned by the University of Oxford, Oxford, UK, to Oxford Immunotec plc, resulting in the T-SPOT.TB test with royalty entitlements for the University of Oxford and AL. AH is named inventor on a patent pertaining to flow-cytometric diagnosis and prognosis of tuberculosis infection and disease. LBC has declared no competing interests exist.

References

    1. World Health Organization (WHO). Global tuberculosis report 2018. 2018 [cited 2019 Mar 22]. Available from: http://apps.who.int/iris/bitstream/handle/10665/274453/9789241565646-eng....
    1. Abubakar I, Drobniewski F, Southern J, Sitch AJ, Jackson C, Lipman M, et al. Prognostic value of interferon-gamma release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study. Lancet Infect Dis. 2018;18(10):1077–87. 10.1016/S1473-3099(18)30355-4 - DOI - PMC - PubMed
    1. Sterling TR, Villarino ME, Borisov AS, Shang N, Gordin F, Bliven-Sizemore E, et al. Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection. New Engl J Med. 2011;365(23):2155–66. 10.1056/NEJMoa1104875 - DOI - PubMed
    1. Swindells S, Ramchandani R, Gupta A, Benson CA, Leon-Cruz J, Mwelase N, et al. One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis. N Engl J Med. 2019;380(11):1001–11. 10.1056/NEJMoa1806808 - DOI - PMC - PubMed
    1. World Health Organization (WHO). Consensus meeting report: development of a target product profile (TPP) and a framework for evaluation for a test for predicting progression from tuberculosis infection to active disease. Report no. WHO/HTM/TB/2017.18 2018 [cited 2019 Mar 22]. Available from: http://www.who.int/iris/handle/10665/259176.

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