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. 2019 Oct:100:101650.
doi: 10.1016/j.jchemneu.2019.101650. Epub 2019 May 22.

MicroRNAs expressed in depression and their associated pathways: A systematic review and a bioinformatics analysis

Camila Perelló Ferrúa, Roberta Giorgi, Laísa Camerini da Rosa, Cainá Corrêa do Amaral, Gabriele Cordenonzi Ghisleni, Ricardo Tavares Pinheiro, Fernanda Nedel

MicroRNAs expressed in depression and their associated pathways: A systematic review and a bioinformatics analysis

Camila Perelló Ferrúa et al. J Chem Neuroanat. 2019 Oct.

Abstract

Depression is a debilitating mental illness, one of the most prevalent worldwide. MicroRNAs have been studied to better understand the biological mechanisms that regulate this disease. This study review systematically the literature to identify which microRNAs are currently being associated with depression and their related pathways. The electronic search was conducted in PubMed, Scopus, Scielo, ISI Web of Knowledge, and PsycINFO databases, using the search terms "Depressive Disorder" or "Depression" and "MicroRNAs". After, microRNAs that were up and down-regulated in depression were analyzed by bioinformatics. We observed that among the 77 microRNAs cited by included studies, 54 had their levels altered in depressed individuals compared to controls, 30 being up-regulated and 24 down-regulated. The bioinformatics analysis revealed that among the up-regulated microRNAs there were 81 total and 43 union pathways, with 15 presenting a significant difference. Among the down-regulated microRNAs, 67 total and 45 union pathways were found, with 14 presenting a significant difference. The miR-17-5p and let-7a-5p were the most frequently found microRNAs in the statistically significant pathways. In this study a panel of altered microRNAs in depression was created with their related pathways, which is a step towards understanding the complex network of microRNAs in depression.

Keywords: Bioinformatic; Depressive disorder; Signaling pathway; Systematic review; microRNAs.

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Figures

Fig. 1
Fig. 1
Flow diagram of study selection.
Fig. 2
Fig. 2
Panel of microRNAs up- and down-regulated, and pathways associated with depressed patients when compared to controls.
See this image and copyright information in PMC

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