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Review
. 2019 Apr:35:57-62.
doi: 10.1016/j.coviro.2019.04.002. Epub 2019 May 21.

Nucleoside analogues for the treatment of coronavirus infections

Andrea J Pruijssers  1 , Mark R Denison  2
Affiliations
Review

Nucleoside analogues for the treatment of coronavirus infections

Andrea J Pruijssers et al. Curr Opin Virol. 2019 Apr.

Abstract

Recent outbreaks of SARS-Coronavirus and MERS-Coronavirus (CoV) have heightened awareness about the lack of vaccines or antiviral compounds approved for prevention or treatment of human or potential zoonotic CoVs. Anti-CoV drug development has long been challenged by the activity of a 3' to 5' proofreading exoribonuclease unique to CoVs. Recently, a promising nucleoside analogue with broad-spectrum activity against CoVs has been identified. This review will discuss progress made in the development of antiviral nucleoside and nucleotide analogues targeting viral RNA synthesis as effective therapeutics against CoV infections and propose promising strategies for combination therapy.

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Figures

Figure 1
Figure 1
Mechanisms of inhibition by nucleoside and nucleotide analogues. Schematic representation illustrates normal replication by the RdRp (blue sphere), premature chain termination caused by an obligate chain terminator, reduced replication fidelity due to mutagen incorporation, and depletion of pools of naturally occurring nucleotides.
See this image and copyright information in PMC

References

    1. Su S., Wong G., Shi W., Liu J., Lai A.C.K., Zhou J., Liu W., Bi Y., Gao G.F. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016;24:490–502. - PMC - PubMed
    1. Revised U.S. Surveillance Case Definition for Severe Acute Respiratory Syndrome (SARS) and Update on SARS Cases — United States and Worldwide, December 2003. [date unknown]. - PubMed
    1. WHO | Middle East respiratory syndrome coronavirus (MERS-CoV).WHO [date unknown.
    1. Arabi Y.M., Balkhy H.H., Hayden F.G., Bouchama A., Luke T., Baillie J.K., Al-Omari A., Hajeer A.H., Senga M., Denison M.R. Middle east respiratory syndrome. N Engl J Med. 2017;376:584–594. - PMC - PubMed
    1. Luo C.-M., Wang N., Yang X.-L., Liu H.-Z., Zhang W., Li B., Hu B., Peng C., Geng Q.-B., Zhu G.-J. Discovery of novel bat coronaviruses in South China that use the same receptor as middle east respiratory syndrome coronavirus. J Virol. 2018;92 - PMC - PubMed

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