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Review
. 2019 Aug:59:97-103.
doi: 10.1016/j.ceb.2019.03.015. Epub 2019 May 21.

Intravital microscopy in mammalian multicellular organisms

Seham Ebrahim  1 , Roberto Weigert  2
Affiliations
Review

Intravital microscopy in mammalian multicellular organisms

Seham Ebrahim et al. Curr Opin Cell Biol. 2019 Aug.

Abstract

Imaging subcellular processes in live animals is no longer a dream. The development of Intravital Subcellular Microscopy (ISMic) combined with the astounding repertoire of available mouse models makes it possible to investigate processes such as membrane trafficking in mammalian living tissues under native conditions. This has provided the unique opportunity to answer questions that cannot be otherwise addressed in reductionist model systems and to link cell biology to tissue pathophysiology.

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