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Review
. 2019 May 24;12(1):51.
doi: 10.1186/s13045-019-0734-5.

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

Yan Liu  1   2   3 , Zhiheng Cheng  4 , Yifan Pang  5 , Longzhen Cui  2 , Tingting Qian  1   3 , Liang Quan  1   3 , Hongyou Zhao  6 , Jinlong Shi  7 , Xiaoyan Ke  8 , Lin Fu  9   10   11
Affiliations
Review

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

Yan Liu et al. J Hematol Oncol. .

Abstract

Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity and mortality in older patients. Although researches over the past decades have improved our understanding of AML, its pathogenesis has not yet been fully elucidated. Long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are three noncoding RNA (ncRNA) molecules that regulate DNA transcription and translation. With the development of RNA-Seq technology, more and more ncRNAs that are closely related to AML leukemogenesis have been discovered. Numerous studies have found that these ncRNAs play an important role in leukemia cell proliferation, differentiation, and apoptosis. Some may potentially be used as prognostic biomarkers. In this systematic review, we briefly described the characteristics and molecular functions of three groups of ncRNAs, including lncRNAs, miRNAs, and circRNAs, and discussed their relationships with AML in detail.

Keywords: Acute myeloid leukemia; Long noncoding RNA; circRNA; microRNA.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The connections of three ncRNAs involved in AML
See this image and copyright information in PMC

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