Targeting VCAM1 rejuvenates the brain in aged mice

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Yvonne Bordon. Nat Rev Immunol. 2019 Jul.

. 2019 Jul;19(7):415.

doi: 10.1038/s41577-019-0183-y.

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Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.
Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter MS, Quake SR, Butcher EC, Wyss-Coray T. Yousef H, et al. Nat Med. 2019 Jun;25(6):988-1000. doi: 10.1038/s41591-019-0440-4. Epub 2019 May 13. Nat Med. 2019. PMID: 31086348 Free PMC article.

1. Yousef, H. et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat. Med. https://doi.org/10.1038/s41591-019-0440-4 (2019) - DOI - PubMed