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Review
. 2019 Aug;97(7):625-635.
doi: 10.1111/imcb.12273. Epub 2019 Jun 5.

The microbiome and immune memory formation

Kathy D McCoy  1 , Regula Burkhard  2 , Markus B Geuking  2
Affiliations
Review

The microbiome and immune memory formation

Kathy D McCoy et al. Immunol Cell Biol. 2019 Aug.

Abstract

The microbiota plays an important role in regulating both the innate and adaptive immune systems. Many studies have focused on the ability of microbes to shape the immune system by stimulating B-cell and antibody responses and the differentiation of T helper cell function. However, an important feature of the immune system is its ability to generate memory responses, which provide increased survival for the host. This review will highlight the role of the microbiota in the induction of immune memory with a focus on both adaptive and innate memory as well as vaccine efficacy.

Keywords: T-cell memory; adaptive immunity; antibody; immune memory; innate immunity; innate memory; microbiota; trained immunity.

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References

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