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Multicenter Study
. 2019 Oct 1;104(10):4356-4364.
doi: 10.1210/jc.2018-02763.

Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study

Viral N Shah  1 , Stephanie N DuBose  2 , Zoey Li  2 , Roy W Beck  2 , Anne L Peters  3 , Ruth S Weinstock  4 , Davida Kruger  5 , Michael Tansey  6 , David Sparling  7 , Stephanie Woerner  8 , Francesco Vendrame  9 , Richard Bergenstal  10 , William V Tamborlane  11 , Sara E Watson  12 , Jennifer Sherr  11
Affiliations
Multicenter Study

Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study

Viral N Shah et al. J Clin Endocrinol Metab. .

Erratum in

Abstract

Context: Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. Although data on glycemic profiles of healthy, nondiabetic individuals exist for older sensors, assessment of glycemic metrics with new-generation CGM devices is lacking.

Objective: To establish reference sensor glucose ranges in healthy, nondiabetic individuals across different age groups using a current generation CGM sensor.

Design: Multicenter, prospective study.

Setting: Twelve centers within the T1D Exchange Clinic Network.

Patients or participants: Nonpregnant, healthy, nondiabetic children and adults (age ≥6 years) with nonobese body mass index.

Intervention: Each participant wore a blinded Dexcom G6 CGM, with once-daily calibration, for up to 10 days.

Main outcome measures: CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability.

Results: A total of 153 participants (age 7 to 80 years) were included in the analyses. Mean average glucose was 98 to 99 mg/dL (5.4 to 5.5 mmol/L) for all age groups except those over 60 years, in whom mean average glucose was 104 mg/dL (5.8 mmol/L). The median time between 70 to 140 mg/dL (3.9 to 7.8 mmol/L) was 96% (interquartile range, 93 to 98). Mean within-individual coefficient of variation was 17 ± 3%. Median time spent with glucose levels >140 mg/dL was 2.1% (30 min/d), and median time spent with glucose levels <70 mg/dL (3.9 mmol/L) was 1.1% (15 min/d).

Conclusion: By assessing across age groups in a healthy, nondiabetic population, normative sensor glucose data have been derived and will be useful as a benchmark for future research studies.

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Figures

Figure 1.
Figure 1.
Cumulative distribution function of hypoglycemia (n = 153). (A) Overall. (B) Daytime (6:00 am to 11:59 pm). (C) Nighttime (12:00 am to 5:59 am).
Figure 2.
Figure 2.
Cumulative distribution function of hyperglycemia (n = 153). (A) Overall. (B) Daytime (6:00 am to 11:59 pm). (C) Nighttime (12:00 am to 5:59 am). aNone of the participants had CGM readings >250 mg/dL during the night.
Figure 3.
Figure 3.
Distribution of CGM glucose values (n = 153). (A) Overall. (B) Daytime (6:00 am to 11:59 pm) and nighttime (12:00 am to 5:59 am).
See this image and copyright information in PMC

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