Spatial memory and navigation in ageing: A systematic review of MRI and fMRI studies in healthy participants

Abstract

Aim: Spatial deficits are widely observed in normal ageing and early Alzheimer's disease. This review systematically examined neuroimaging evidence for structural and functional differences in the hippocampus (HC) associated with non-pathological age-related changes in allocentric spatial abilities.

Methods: Databases were searched to identify peer-reviewed studies on allocentric spatial processing in normal ageing including MRI or fMRI data. 15 eligible studies were reviewed after applying exclusion criteria and quality assessment.

Results: There was a marked deficit in allocentric spatial processing and trend towards egocentric strategies in older adults when compared to young controls or across the lifespan, associated in the majority of studies with HC volumetric changes, metabolic or microstructural indicators, and underactivity. A few studies reported no significant correlations.

Conclusion: Findings confirm literature supporting an age-related allocentric spatial processing deficit and a shift towards egocentric strategies. A majority of studies implicated HC atrophy, microstructural/metabolic alterations or functional changes in age-related allocentric spatial impairment. More sensitive imaging techniques and ecologically valid spatial tasks are needed to detect subtle changes in the HC and brain's navigational network.

Keywords: Ageing; Allocentric spatial processing; Neuroimaging; Spatial memory; Spatial navigation.