Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3)

doi:10.1136/bmjopen-2018-026646

Observational Study

. 2019 May 24;9(5):e026646.

doi: 10.1136/bmjopen-2018-026646.

Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3)

NIHR Global Health Research Uniton Global Surgery

Collaborators

NIHR Global Health Research Uniton Global Surgery:
Stephen R Knight, Thomas M Drake, Dmitri Nepogodiev, J Edward F Fitzgerald, Adesoji O Ademuyiwa, Philip Alexander, Jean C Allen Ingabire, Sara W Al-Saqqa, Bruce Biccard, Giuliano Borda, David Borowski, Sule Burger, Kathryn Chu, Damian Clarke, Ainhoa Costa, Justine Davies, Rachel Donaldson, Chikwendu Ede, O James Garden, Dhruv Ghosh, James C Glasbey, T Peter Kingham, Hosni Khairy Salem, Anyomih Theophilus Kojo, Zach Koto, Marie Carmela Lapitan, Ismail Lawani, Chiapo Lesetedi, Maria Lorena Aguilera, Charles Mabedi, Mayaba Maimbo, Laura Magill, Felix Makinde Alakaloko, Alex Makupe, Janet Martin, Antonio Ramos-de La Medina, Mark Monahan, Rachel Moore, Vanessa Msosa, Soloman Mulira, Alphonse Zeta Mutabazi, Elmi Muller, Joseph Musowoyo, Adewale Oluseye Adisa, Jean Léon Olory-Togbe, Riinu Ots, Ahmad Uzair Qureshi, Sarah Rayne, Tracey Roberts, Marie Dione Parreno-Sacdalan, Catherine Shaw, Neil Smart, Martin Smith, Richard Spence, Steph Van Straten, Stephen Tabiri, Viki Tayler, Thomas G Weiser, John Windsor, Joseph Yorke, Raul Yepez, Richard Lilford, Dion Morton, Aneel Bhangu, Sudha Sundar, Ewen M Harrison

PMID: 31129582
PMCID: PMC6538014
DOI: 10.1136/bmjopen-2018-026646

Observational Study

Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3)

NIHR Global Health Research Uniton Global Surgery. BMJ Open. 2019.

. 2019 May 24;9(5):e026646.

doi: 10.1136/bmjopen-2018-026646.

Author

NIHR Global Health Research Uniton Global Surgery

Collaborators

NIHR Global Health Research Uniton Global Surgery:
Stephen R Knight, Thomas M Drake, Dmitri Nepogodiev, J Edward F Fitzgerald, Adesoji O Ademuyiwa, Philip Alexander, Jean C Allen Ingabire, Sara W Al-Saqqa, Bruce Biccard, Giuliano Borda, David Borowski, Sule Burger, Kathryn Chu, Damian Clarke, Ainhoa Costa, Justine Davies, Rachel Donaldson, Chikwendu Ede, O James Garden, Dhruv Ghosh, James C Glasbey, T Peter Kingham, Hosni Khairy Salem, Anyomih Theophilus Kojo, Zach Koto, Marie Carmela Lapitan, Ismail Lawani, Chiapo Lesetedi, Maria Lorena Aguilera, Charles Mabedi, Mayaba Maimbo, Laura Magill, Felix Makinde Alakaloko, Alex Makupe, Janet Martin, Antonio Ramos-de La Medina, Mark Monahan, Rachel Moore, Vanessa Msosa, Soloman Mulira, Alphonse Zeta Mutabazi, Elmi Muller, Joseph Musowoyo, Adewale Oluseye Adisa, Jean Léon Olory-Togbe, Riinu Ots, Ahmad Uzair Qureshi, Sarah Rayne, Tracey Roberts, Marie Dione Parreno-Sacdalan, Catherine Shaw, Neil Smart, Martin Smith, Richard Spence, Steph Van Straten, Stephen Tabiri, Viki Tayler, Thomas G Weiser, John Windsor, Joseph Yorke, Raul Yepez, Richard Lilford, Dion Morton, Aneel Bhangu, Sudha Sundar, Ewen M Harrison

PMID: 31129582
PMCID: PMC6538014
DOI: 10.1136/bmjopen-2018-026646

Abstract

Introduction: Empirical, observational data relating to the diagnosis, management and outcome of three common worldwide cancers requiring surgery is lacking. However, it has been demonstrated that patients in low/middle-income countries undergoing surgery for cancer are at increased risk of death and major complications postoperatively. This study aims to determine quality and outcomes in breast, gastric and colorectal cancer surgery across worldwide hospital settings.

Methods and analysis: This multicentre, international prospective cohort study will be undertaken by any hospital providing emergency or elective surgical services for breast, gastric or colorectal cancer. Centres will collect observational data on consecutive patients undergoing primary emergency or elective surgery for breast, gastric or colorectal cancer during a 6-month period. The primary outcome is the incidence of mortality and major complication rate at 30 days after cancer surgery. Infrastructure and care processes in the treatment of these cancers worldwide will also be characterised.

Ethics and dissemination: This project will not affect clinical practice and has been classified as clinical audit following research ethics review. The protocol will be disseminated through the international GlobalSurg network.

Trial registration number: NCT03471494; Pre-results.

Keywords: cancer; global surgery; mortality; perioperative care; perioperative complications; quality.

PubMed Disclaimer

Conflict of interest statement

Competing interests: GlobalSurg is run by the Surgical Research Gateway (SuRG) Foundation. The SuRG Foundation is a registered charity (charity number 1159898) whose object is to advanced the education of medical students and doctors in surgical science, clinical research and audit methods by promoting participation in collaborative clinical research and audit studies.

Cited by

Preliminary study demonstrating cancer cells detection at the margins of whole glioblastoma specimens with Raman spectroscopy imaging.
Daoust F, Dallaire F, Tavera H, Ember K, Guiot MC, Petrecca K, Leblond F. Daoust F, et al. Sci Rep. 2025 Feb 22;15(1):6453. doi: 10.1038/s41598-025-87109-1. Sci Rep. 2025. PMID: 39987144 Free PMC article.
Comparison of short-term outcomes from the International Oesophago-Gastric Anastomosis Audit (OGAA), the Esophagectomy Complications Consensus Group (ECCG), and the Dutch Upper Gastrointestinal Cancer Audit (DUCA).
Oesophago-Gastric Anastomosis Study Group on behalf of the West Midlands Research Collaborative. Oesophago-Gastric Anastomosis Study Group on behalf of the West Midlands Research Collaborative. BJS Open. 2021 May 7;5(3):zrab010. doi: 10.1093/bjsopen/zrab010. BJS Open. 2021. PMID: 35179183 Free PMC article.
Audit of surgical services in a teaching hospital in Addis Ababa, Ethiopia.
Gebresellassie HW, Tamerat G. Gebresellassie HW, et al. BMC Res Notes. 2019 Oct 22;12(1):678. doi: 10.1186/s13104-019-4709-y. BMC Res Notes. 2019. PMID: 31640817 Free PMC article.
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study.
GlobalSurg Collaborative and NIHR Global Health Research Unit on Global Surgery. GlobalSurg Collaborative and NIHR Global Health Research Unit on Global Surgery. Lancet Glob Health. 2022 Jul;10(7):e1003-e1011. doi: 10.1016/S2214-109X(22)00168-1. Epub 2022 May 24. Lancet Glob Health. 2022. PMID: 35623378 Free PMC article.
Call for intervention and analysis of the rise in young-onset gastrointestinal cancers in low- and middle-income countries: an editorial.
Bharadwaj HR, Aderinto N, Hasham Ali S, Kirani Tan J, Dhali A, Abbasher Hussein Mohamed Ahmed K. Bharadwaj HR, et al. Ann Med Surg (Lond). 2024 Mar 19;86(5):2402-2404. doi: 10.1097/MS9.0000000000001964. eCollection 2024 May. Ann Med Surg (Lond). 2024. PMID: 38694330 Free PMC article. No abstract available.

See all "Cited by" articles

References

1. Sullivan R, Alatise OI, Anderson BO, et al. . Global cancer surgery: delivering safe, affordable, and timely cancer surgery. Lancet Oncol 2015;16:1193–224. 10.1016/S1470-2045(15)00223-5 - DOI - PubMed
1. Fitzmaurice C, Allen C, Barber RM, et al. . Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol 2017;3:524 10.1001/jamaoncol.2016.5688 - DOI - PMC - PubMed
1. Alkire BC, Raykar NP, Shrime MG, et al. . Global access to surgical care: a modelling study. Lancet Glob Health 2015;3:e316–e323. 10.1016/S2214-109X(15)70115-4 - DOI - PMC - PubMed
1. GlobalSurg Collaborative. Mortality of emergency abdominal surgery in high-, middle- and low-income countries. Br J Surg 2016;103:971–88. 10.1002/bjs.10151 - DOI - PubMed
1. GlobalSurg Collaborative. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis 2018;18:1–10. 10.1016/S1473-3099(18)30101-4 - DOI - PMC - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Associated data

Actions
- Search in PubMed
- Search in ClinicalTrials.gov

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information

[1] Sullivan R, Alatise OI, Anderson BO, et al. . Global cancer surgery: delivering safe, affordable, and timely cancer surgery. Lancet Oncol 2015;16:1193–224. 10.1016/S1470-2045(15)00223-5 - DOI - PubMed

[2] Sullivan R, Alatise OI, Anderson BO, et al. . Global cancer surgery: delivering safe, affordable, and timely cancer surgery. Lancet Oncol 2015;16:1193–224. 10.1016/S1470-2045(15)00223-5 - DOI - PubMed

[3] Fitzmaurice C, Allen C, Barber RM, et al. . Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol 2017;3:524 10.1001/jamaoncol.2016.5688 - DOI - PMC - PubMed

[4] Fitzmaurice C, Allen C, Barber RM, et al. . Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol 2017;3:524 10.1001/jamaoncol.2016.5688 - DOI - PMC - PubMed

[5] Alkire BC, Raykar NP, Shrime MG, et al. . Global access to surgical care: a modelling study. Lancet Glob Health 2015;3:e316–e323. 10.1016/S2214-109X(15)70115-4 - DOI - PMC - PubMed

[6] Alkire BC, Raykar NP, Shrime MG, et al. . Global access to surgical care: a modelling study. Lancet Glob Health 2015;3:e316–e323. 10.1016/S2214-109X(15)70115-4 - DOI - PMC - PubMed

[7] GlobalSurg Collaborative. Mortality of emergency abdominal surgery in high-, middle- and low-income countries. Br J Surg 2016;103:971–88. 10.1002/bjs.10151 - DOI - PubMed

[8] GlobalSurg Collaborative. Mortality of emergency abdominal surgery in high-, middle- and low-income countries. Br J Surg 2016;103:971–88. 10.1002/bjs.10151 - DOI - PubMed

[9] GlobalSurg Collaborative. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis 2018;18:1–10. 10.1016/S1473-3099(18)30101-4 - DOI - PMC - PubMed

[10] GlobalSurg Collaborative. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis 2018;18:1–10. 10.1016/S1473-3099(18)30101-4 - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3)

Collaborators

Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3)

Author

Collaborators

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Associated data

Grants and funding

LinkOut - more resources

Full Text Sources

Medical