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Meta-Analysis
. 2019 May 25;14(1):55.
doi: 10.1007/s11657-019-0604-3.

Age-specific 1-year mortality rates after hip fracture based on the populations in mainland China between the years 2000 and 2018: a systematic analysis

Zhiyong Cui  1   2 , Hui Feng  1 , Xiangyu Meng  3 , Siying Zhuang  4 , Zhaorui Liu  5 , Kaifeng Ye  1   2 , Chuan Sun  1   2 , Yong Xing  1   2 , Fang Zhou  1 , Yun Tian  6
Affiliations
Meta-Analysis

Age-specific 1-year mortality rates after hip fracture based on the populations in mainland China between the years 2000 and 2018: a systematic analysis

Zhiyong Cui et al. Arch Osteoporos. .

Abstract

We used statistical approaches to calculate 1-year mortality rates and reveal the relationship between age and the 1-year mortality rate after hip fracture based on data from mainland China between the years 2000 and 2018.

Introduction: Data on the 1-year mortality rates after hip fracture in mainland China remain limited and localized. We aimed to analyze the 1-year mortality rates and reveal the variations in 1-year mortality by age after hip fracture based on data from mainland China.

Methods: We searched PubMed, EMBASE, Cochrane Library, CNKI, Wanfang, and CBM-SinoMed for all relevant articles in English or Chinese to estimate the 1-year mortality rates after hip fracture in mainland China. A random-effects meta-analysis model was fitted to pool the overall 1-year mortality rates. A multilevel mixed-effects meta-regression model was developed. Based on the final model, the age-specific 1-year mortality rates after hip fracture in mainland China were generated.

Results: The pooled estimate of the 1-year mortality rate was 13.96% after hip fracture (95% CI 12.26 to 15.86%), 17.47% after femoral intertrochanteric fracture (95% CI 14.29 to 21.20%), and 9.83% after femoral neck fracture (95% CI 6.96 to 13.72%) between the years 2000 and 2018. We found that the 1-year mortality rates ranged from 2.65% (95% CI 1.76 to 3.99%) in those aged 50~54 years to 28.91% (95% CI 24.23 to 34.30%) in those aged 95~99 years after hip fracture; ranged from 1.73% (95% CI 0.58 to 4.99%) in those aged 50~54 years to 50.11% (95% CI 46.03% to 53.97%) in those aged 95~99 years after femoral intertrochanteric fracture; and ranged from 1.66% (95% CI 1.31 to 2.11%) in those aged 60~64 years to 37.71% (95% CI 27.92 to 48.63%) in those aged 95~99 years after femoral neck fracture.

Conclusion: In this systematic review and meta-analysis, we calculated the 1-year mortality rate after hip fracture in mainland China and found that this rate was lower than that in most countries. We also estimated the age-specific mortality rates for different age groups after hip fracture. These findings will be beneficial for the prevention and treatment of hip fracture in mainland China.

Keywords: China; Hip fracture; Meta-analysis; Mortality; Systematic review.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Flowchart of selection of cohort studies of 1-year mortality after hip fracture in mainland China following the MOOSE guideline
Fig. 2
Fig. 2
A map of study locations included in the systematic review in mainland China. Dots indicate the study locations
Fig. 3
Fig. 3
Age-specific 1-year mortality after hip fracture, femoral intertrochanteric fracture, and femoral neck fracture based on the data points from the included studies, with 95% confidence intervals. Note: The size of each bubble is proportional to the sample size. Regression lines are based on only or very few data points at younger (< 70 years) and older (> 90 years) ages. Overall, there were 75 data points for constructing the relationship between age and 1-year mortality after hip fracture, 27 data points for femoral intertrochanteric fracture, and 12 data points for femoral neck fracture
Fig. 4
Fig. 4
Comparison of estimated age-specific 1-year mortality rates between femoral intertrochanteric fracture and femoral neck fracture, with 95% confidence intervals
See this image and copyright information in PMC

References

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