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Review
. 2019 May 16:8:76.
doi: 10.1186/s13756-019-0533-3. eCollection 2019.

Antibiotics versus biofilm: an emerging battleground in microbial communities

Divakar Sharma  1 , Lama Misba  1 , Asad U Khan  1
Affiliations
Review

Antibiotics versus biofilm: an emerging battleground in microbial communities

Divakar Sharma et al. Antimicrob Resist Infect Control. .

Abstract

Biofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group; adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix which is generally composed of eDNA, proteins and polysaccharides, showed high resistance to antibiotics. It is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. Quorum sensing plays an important role in regulating the biofilm formation. There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs.

Keywords: Antibiotics resistance; Biofilm; Drug resistance bacterial infection.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Diagrammatic representation of the potential mechanisms of antibiotic resistance in biofilms communities
Fig. 2
Fig. 2
Diagrammatic representation of the alternative approaches against antibiotic resistant biofilms communities
See this image and copyright information in PMC

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