Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018;5(3):30.
Epub 2018 Nov 27.

Survey of Treatment Preferences for Opioid Use Disorder

Ravi Nahata  1   2 , Michael J Mancino  2 , Jeff Thostenson  3 , Alison H Oliveto  2
Affiliations

Survey of Treatment Preferences for Opioid Use Disorder

Ravi Nahata et al. Jacobs J Addict Ther. 2018.

Abstract

Objectives: This study gathered preliminary information on the initial feasibility of using injection Naltrexone (NTX) therapy in opioid users.

Methods: One hundred opioid users (36% female, 8% minorities, mean age 34.5±11.4 yrs.) undergoing a health screen to determine initial eligibility for an ongoing study completed the survey.

Results: Of the 100 respondents, 26, 16, 16, 1 and 0 reported prior treatment episodes of opioid detoxification, buprenorphine (BUP), methadone (MTD), oral NTX and injection NTX, respectively. Ninety and 71% were interested in participating in a study involving oral and/or injection NTX treatment, respectively. Reasons for not wanting to try injection NTX included fear of needles (n=13), side effects (n=7), lack of pain relief (n=12) and cost (n=3). A significantly higher percentage of those interested in injection NTX had episodes of prior opioid agonist maintenance treatment relative to those uninterested (32.4% vs 10.3%; Chi2=5.2, p<0.03). Those preferring injection NTX therapy showed a higher level of interest in this therapy (3.08±1.01 vs 1.62±1.35; Rank Sum p<0.0001) and a lower degree of interest in BUP treatment (2.96±0.93 vs 3.38±0.90; Rank Sum p< 0.03) than those not preferring injection NTX.

Conclusions: These preliminary results suggest that those with prior, failed experience with opioid agonist maintenance treatment are more likely to consider injection NTX therapy, suggesting it may be optimal as a second-line treatment for OUD.

Keywords: Naltrexone; opioid use disorder; prescription opioids.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declare that they have no conflict of interest to report

Figures

Figure1.
Figure1.
Episodes of prior opioid agonist (i.e., buprenorphine or methadone) maintenance treatment in those interested in Long Acting Injection of Naltrexone relative to those uninterested. Results of those without and with at least one prior treatment episodes are represented by the black columns and white columns, respectively.
Figure 2.
Figure 2.
Reasons provided byparticipants for not considering Long Acting Injection of Naltrexone
See this image and copyright information in PMC

References

    1. SAMHSA, Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings.. NSDUH Series H-38A, HHS Publication No. SMA 10–4586 Findings)., 2010.
    1. DuPont RL, Prescription Drug Abuse: An Epidemic Dilemma. Journal of Psychoactive Drugs, 2010. 42(2): p. 127–132. - PubMed
    1. McCabe SE, et al., Does early onset of non-medical use of prescription drugs predict subsequent prescription drug abuse and dependence? Results from a national study. Addiction (Abingdon, England), 2007. 102(12): p. 1920–1930. - PMC - PubMed
    1. Coben JH, et al., Hospitalizations for Poisoning by Prescription Opioids, Sedatives, and Tranquilizers. American Journal of Preventive Medicine, 2010. 38(5): p. 517–524. - PubMed
    1. Cai R, et al., Emergency Department Visits Involving Nonmedical Use of Selected Prescription Drugs in the United States, 2004–2008. Vol. 24 2010. 293–7. - PubMed

LinkOut - more resources