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. 2020 Jan 2;70(2):323-326.
doi: 10.1093/cid/ciz430.

Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

Kevin L Steiner  1 , Mamun Kabir  2 , Jeffrey W Priest  3 , Biplob Hossain  2 , Carol A Gilchrist  1 , Heather Cook  4 , Jennie Z Ma  5 , Poonum S Korpe  6 , Tahmeed Ahmed  2 , A S G Faruque  2 , Rashidul Haque  2 , William A Petri  1
Affiliations

Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

Kevin L Steiner et al. Clin Infect Dis. .

Abstract

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Keywords: Cp23; IgA; cryptosporidiosis; fecal; mucosal.

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Figures

Figure 1.
Figure 1.
Kaplan-Meier curve showing probability of survival free of Cryptosporidium species during the second year of life among infants (n = 442), stratified by amount of anti-Cp23 immunoglobulin. A, No difference in subsequent cryptosporidiosis-free survival between children in the upper 50th (orange) and lower 50th percentile (blue) of plasma anti-Cp23 immunoglobulin G measured at 1 year of life. B, Children in the upper 50th percentile (orange) of fecal anti-Cp23 immunoglobulin A measured at 1 year of life had a statistically significantly longer subsequent cryptosporidiosis-free survival compared to children in the lower 50th percentile (blue). The y-axis represents the survival probability free from infection, and the x-axis is survival time in days, from 1 to 2 years of life. P values by log-rank test.
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