Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2019 Nov;41(1):393-400.
doi: 10.1080/0886022X.2019.1603110.

High sensitivity Troponin-I levels in asymptomatic hemodialysis patients

Tanawat Tarapan  1 , Khrongwong Musikatavorn  1   2 , Piyarat Phairatwet  3 , Kullaya Takkavatakarn  4 , Paweena Susantitaphong  4 , Somchai Eiam-Ong  4 , Khajohn Tiranathanagul  4
Affiliations
Comparative Study

High sensitivity Troponin-I levels in asymptomatic hemodialysis patients

Tanawat Tarapan et al. Ren Fail. 2019 Nov.

Abstract

Reduction in renal clearance and removal by hemodialysis adversely affect the level and utility of high-sensitivity troponin I (hsTnI) for diagnosis of acute myocardial infarction (AMI) in hemodialysis (HD) patients. Furthermore, HD process itself might cause undesirable myocardial injury and enhance post HD hsTnI levels. This comparative cross-sectional study was conducted to compare the hsTnI levels between 100 asymptomatic HD patients and their 107 matched non-chronic kidney disease (CKD) population. The hsTnI levels in HD group were higher than non-CKD group [median (IQR): 54.3 (20.6-152.7) vs. 18 (6.2-66.1) ng/L, p < .001)]. The hsTnI levels reduced after HD process from 54.3 (20.6-152.7) ng/L in pre-HD to 27.1 (12.3-91.4) ng/L in post-HD (p = .015). Of interest, 25% of HD patients had increment of hsTnI after HD and might represent HD-induced myocardial injury. The significant risk factors were high hemoglobin level and high blood flow rate. In conclusion, the baseline hsTnI levels in asymptomatic HD patients were higher than non-CKD population. The dynamic change of hsTnI over time would be essential for the diagnosis of AMI. Certain numbers of asymptomatic HD patients had HD-induced silent myocardial injury and should be aggressively investigated to prevent further cardiovascular mortality.

Keywords: Hemodialysis; Troponin I; myocardial injury.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The baseline of hsTnI in asymptomatic non-CKD group and pre-dialysis HD group as well as post-dialysis in HD group.
See this image and copyright information in PMC

References

    1. Labugger R, Organ L, Collier C, et al. . Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation. 2000;102:1221–1226. - PubMed
    1. Leszyk J, Dumaswala R, Potter JD, et al. . Amino acid sequence of bovine cardiac troponin I. Biochemistry. 1988;27:2821–2827. - PubMed
    1. Thygesen K, Alpert JS, White HD, et al. . Universal definition of myocardial infarction. Circulation. 2007;116:2634–2653. - PubMed
    1. Bonaca MP, Wiviott SD, Braunwald E, et al. . American College of Cardiology/American Heart Association/European Society of Cardiology/World Heart Federation universal definition of myocardial infarction classification system and the risk of cardiovascular death: observations from the TRITON-TIMI 38 trial (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38). Circulation. 2012;125:577–583. - PubMed
    1. Thygesen K, Alpert JS, Jaffe AS, et al. . Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2551–2567. - PubMed

Publication types

MeSH terms