Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Jul;40(7):555-556.
doi: 10.1016/j.it.2019.05.005. Epub 2019 May 24.

Microglia and Neutrophils to the Rescue

Mihaela Gadjeva  1
Affiliations
Comment

Microglia and Neutrophils to the Rescue

Mihaela Gadjeva. Trends Immunol. 2019 Jul.

Abstract

Invasive candidiasis is a medical condition that is challenging to treat. A recent study (Drummond et al.Nat. Immunol. 2019;20:559-570) reveals new insights into the role of microglia and neutrophils in limiting fungal dissemination to the mouse brain. Gaining knowledge into tissue-specific protection mechanisms may ensure improved prognosis and disease management against fungal infections.

Keywords: fungal infection; innate immunity; microglia; neutrophils.

PubMed Disclaimer

Comment on

References

    1. Salazar F, and Brown GD (2018) Antifungal Innate Immunity: A Perspective from the Last 10 Years. J Innate Immun 10, 373–397 - PMC - PubMed
    1. Hirano R, Sakamoto Y, Kudo K, and Ohnishi M (2015) Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience. Infect Drug Resist 8, 199–205 - PMC - PubMed
    1. Gavino C, Cotter A, Lichtenstein D, Lejtenyi D, Fortin C, Legault C, Alirezaie N, Majewski J, Sheppard DC, Behr MA, Foulkes WD, and Vinh DC (2014) CARD9 deficiency and spontaneous central nervous system candidiasis: complete clinical remission with GM-CSF therapy. Clin Infect Dis 59, 81–84 - PMC - PubMed
    1. Drewniak A, Gazendam RP, Tool AT, van Houdt M, Jansen MH, van Hamme JL, van Leeuwen EM, Roos D, Scalais E, de Beaufort C, Janssen H, van den Berg TK, and Kuijpers TW (2013) Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood 121, 2385–2392 - PubMed
    1. Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, and Lionakis MS (2019) CARD9(+) microglia promote antifungal immunity via IL-1beta- and CXCL1-mediated neutrophil recruitment. Nat Immunol 20, 559–570 - PMC - PubMed

Publication types

Substances