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. 2019 Jun 12;17(23):5693-5697.
doi: 10.1039/c9ob01038f.

Importance of the main chain of lysine for histone lysine methyltransferase catalysis

Abbas H K Al Temimi  1 , Ruben S Teeuwen, Vu Tran, Arthur J Altunc, Danny C Lenstra, Wansheng Ren, Ping Qian, Hong Guo, Jasmin Mecinović
Affiliations

Importance of the main chain of lysine for histone lysine methyltransferase catalysis

Abbas H K Al Temimi et al. Org Biomol Chem. .

Abstract

Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and other proteins. Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.

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