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. 2019 Jul;36(7):1449-1456.
doi: 10.1007/s10815-019-01490-1. Epub 2019 May 27.

Hypertensive disorders of pregnancy and infertility treatment: a population-based survey among United States women

Brent C Monseur  1 , Jerrine R Morris  2 , Heather S Hipp  3 , Vincenzo Berghella  4
Affiliations

Hypertensive disorders of pregnancy and infertility treatment: a population-based survey among United States women

Brent C Monseur et al. J Assist Reprod Genet. 2019 Jul.

Abstract

Purpose: To explore associations between infertility treatment and hypertensive disorders of pregnancy.

Methods: We collated multi-year as well as multi-state data from a national representative survey examining the association between self-reported infertility treatment (i.e., medication, intrauterine insemination, or assisted reproductive technology) and hypertensive disorders of pregnancy (i.e., high blood pressure, pregnancy-induced hypertension (PIH), preeclampsia, and toxemia). Data were analyzed using logistic regression. A total of 21,884 women in the United States (U.S.), from the Centers for Disease Control and Prevention's (CDC) Pregnancy Risk Assessment Monitoring System (PRAMS) survey (2009-2015), participated in the study.

Results: In our analysis, 12.91% women reported a history of infertility treatment and 15.19% reported a history of hypertensive disorder of pregnancy. Compared with women who had never had infertility treatment, women who reported infertility treatment had 1.18 (adjusted OR, 95% confidence interval (CI) 1.05, 1.33) higher odds of reporting hypertensive disorder of pregnancy. Neither types of infertility treatment nor proximity of treatment to pregnancy were independently associated with hypertensive disorder of pregnancy.

Conclusions: Our results suggest that among U.S. women, the treatment of infertility may be associated with hypertension disorder of pregnancy regardless of type of treatment.

Keywords: Cardiovascular disease; Hypertension; Infertility; PRAMS; Reproductive health.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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