Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct;110(4):512-516.
doi: 10.1007/s12185-019-02665-3. Epub 2019 May 27.

Successful treatment of acute myeloid leukemia co-expressing NUP98/NSD1 and FLT3/ITD with preemptive donor lymphocyte infusions

Yuichi Mitani  1 , Mitsuteru Hiwatari  2 , Masafumi Seki  1 , Mayumi Hangai  1 , Junko Takita  1   3
Affiliations

Successful treatment of acute myeloid leukemia co-expressing NUP98/NSD1 and FLT3/ITD with preemptive donor lymphocyte infusions

Yuichi Mitani et al. Int J Hematol. 2019 Oct.

Abstract

Patients with acute myeloid leukemia (AML) co-expressing NUP98/NSD1 and FLT3/ITD have a dismal prognosis despite undergoing hematopoietic stem cell transplantation (HSCT). There are a few studies on successful treatment of relapsed AML co-expressing NUP98/NSD1 and FLT3/ITD. We report a refractory case of molecular relapse of AML co-expressing NUP98/NSD1 and FLT3/ITD post-matched sibling HSCT. Donor lymphocyte infusion (DLI) at an early stage of post-transplantation resulted in complete molecular remission for 29 months with durable chronic graft-versus-host disease. Our case suggests the clinical efficacy of preemptive DLI following minimal residual disease analysis for the treatment of refractory AML.

Keywords: Acute myeloid leukemia; FLT3/ITD; NUP98/NSD1; Peripheral blood stem cell transplantation; Preemptive donor lymphocyte infusions.

PubMed Disclaimer

References

    1. Blood. 2000 Jan 1;95(1):67-71 - PubMed
    1. Bone Marrow Transplant. 2000 Oct;26(7):769-74 - PubMed
    1. Blood. 2002 Jul 15;100(2):397-405 - PubMed
    1. Blood. 2002 Nov 1;100(9):3108-14 - PubMed
    1. J Clin Oncol. 2003 Dec 15;21(24):4642-9 - PubMed

LinkOut - more resources