Design of Cyclic Peptides as Protein Recognition Motifs

Abstract

Protein-protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Linear peptide drugs, however, can be applied therapeutically as protein recognition motifs only to a limited extent because of their poor permeability, decreased receptor selectivity, and proteolytic stability. A major strategy in peptide chemistry is directed toward chemical modification and macrocyclization in order to limit a peptide's conformational possibilities, to increase its chemical and enzymatic stability, to prolong the time of action, and to increase activity and selectivity toward the receptor.

Keywords: Conformationally constrained peptides; Macrocyclization; Protein surface mimetics; Protein–peptide interaction; Reverse turn; α-Helix; β-Strand.