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. 2019:2001:273-284.
doi: 10.1007/978-1-4939-9504-2_12.

DNA-Encoded Macrocyclic Peptide Library

Zhengrong Zhu  1 , Alex Shaginian  2 , La Shadric C Grady  2 , Christopher P Davie  2 , Kenneth Lind  2 , Sandeep Pal  3 , Praew Thansandote  3 , Graham L Simpson  3
Affiliations

DNA-Encoded Macrocyclic Peptide Library

Zhengrong Zhu et al. Methods Mol Biol. 2019.

Abstract

DNA-encoded library technology (ELT) is a cutting-edge enabling technology platform for drug discovery. Here we describe how to design and synthesize a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity. This approach provides an effective tool for pharmaceutical research based on peptides.

Keywords: Affinity selection; DNA-encoded library; Macrocyclic peptides.

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