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. 1979;58(2):227-31.
doi: 10.1159/000232196.

Alterations in granulation tissue growth induced in vivo by lymphocytes from adjuvant-diseased rats

M J Parnham, G A Schoester, T H van der Kwast, R Benner

Alterations in granulation tissue growth induced in vivo by lymphocytes from adjuvant-diseased rats

M J Parnham et al. Int Arch Allergy Appl Immunol. 1979.

Abstract

Lymph node cells from Lewis and Wistar rats, treated 9 or 11 days previously with Freund's complete (FCA) or incomplete adjuvant (FIA), were transferred into polyether sponges implanted subcutaneously into syngeneic, recipient rats. FCA-treated lymphocytes enhanced or reduced granuloma formation (measured after 8 days), when compared with FIA-treated controls, depending on the strain of mycobacterium present in the FCA. The stimulatory effects of lymphocytes from FCA-treated, Lewis rats were abolished by pre-incubation with mitomycin C (25 microgram/ml). Whole serum and isolated serum immunoglobulin from adjuvant-diseased rats had no effect on the sponge granulomas. These data confirm that cell-mediated immunity is involved in the articular granuloma formation of adjuvant arthritis.

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