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. 1987 Jan;67(1):5-10.

Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice

J H Playfair, J B De Souza

Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice

J H Playfair et al. Clin Exp Immunol. 1987 Jan.

Abstract

Mice were protected against lethal Plasmodium yoelii malaria by vaccination with a Triton X-100 lysate of whole parasitized erythrocytes. For full effectiveness this vaccine required an adjuvant, and we have found that recombinant gamma-interferon has strong adjuvanticity in this model when given either intraperitoneally or subcutaneously. Specific immune responses that were enhanced included antibody, T cell help, and delayed hypersensitivity.

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