Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May 28;20(1):33.
doi: 10.1186/s40360-019-0309-7.

Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities

Alireza Neshani  1   2   3 , Hosna Zare  1   2 , Mohammad Reza Akbari Eidgahi  4 , Azad Khaledi  5 , Kiarash Ghazvini  6   7
Affiliations
Review

Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities

Alireza Neshani et al. BMC Pharmacol Toxicol. .

Abstract

Background: Antibiotic-resistant pathogens are an emerging threat in this century. Epinecidin-1 is a multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides) has been shown to have extensive potentials as an alternative for current antibiotics. Due to the huge costs for the study and the production of a new drug, if an antimicrobial peptide has other beneficial functions in addition to antimicrobial activities, it would be preferred.

Methods: In this study, properties and applications of Epinecidin-1 were investigated and addressed comprehensively. To achieve this, the Google Scholar search engine and three databases of PubMed, Scopus, and Web of Science were used.

Results: Epinecidin-1 is a cationic AMP with an alpha-helical structure. Seven functional usages of this peptide have been reported in the literature including antibacterial, antifungal, antiviral, antiprotozoal, anticancer, immunomodulatory, and wound healing properties. Moreover, this peptide has high potential to be used as an active ingredient in cleaning solutions as well as application in vaccine production.

Conclusion: Due to significant antimicrobial activities tested on bacteria such as Staphylococcus aureus and Helicobacter pylori and also wound healing properties, Epi-1 has high potential to be considered as an important candidate for the production of new drugs and treatment of various infections including diabetic foot ulcer and peptic ulcer. Moreover, adjuvant-like properties of Epi-1 make it a suitable candidate for the studies related to an adjuvant. Other attractive properties such as anticancer effects have also been reported for this peptide which encourages further studies on this peptide.

Keywords: Anticancer; Antimicrobial peptide; Epinecidin-1; Epinephelus coioides; Immune response.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Orange-spotted grouper (Epinephelus coioides)
Fig. 2
Fig. 2
The spatial organization of Epinecidin-1 derivatives. Helical wheel diagrams (up) [7, 16], three-dimensional structure (down) [17]
See this image and copyright information in PMC

References

    1. Tacconelli E, Magrini N, Kahlmeter G, Singh N. Global priority list of antibiotic-resistant bacteria to guide research. Discovery, and development of new antibiotics. Geneva: WHO; 2017.
    1. Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318–327. doi: 10.1016/S1473-3099(17)30753-3. - DOI - PubMed
    1. Wang G, Li X, Wang Z. APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Res. 2015;44(D1):D1087–D1093. doi: 10.1093/nar/gkv1278. - DOI - PMC - PubMed
    1. Müller AT, Gabernet G, Hiss JA, Schneider G. modlAMP: Python for antimicrobial peptides. Bioinformatics. 2017;33(17):2753–2755. doi: 10.1093/bioinformatics/btx285. - DOI - PubMed
    1. Neshani Alireza, Zare Hosna, Akbari Eidgahi Mohammad Reza, Hooshyar Chichaklu Amin, Movaqar Aref, Ghazvini Kiarash. Review of antimicrobial peptides with anti-Helicobacter pylori activity. Helicobacter. 2018;24(1):e12555. doi: 10.1111/hel.12555. - DOI - PubMed

MeSH terms

LinkOut - more resources