Effect of exercise on colorectal cancer prevention and treatment

Abstract

In recent years, because of improved cancer screening, detection and treatment modalities, a rapid increase in the population of colorectal and other cancer survivors has been observed. The increasing population has justified the requirement of preventive strategies such as lifestyle modifications with regard to obesity, physical activity, diet and smoking. Physical activity may prevent approximately 15% of the colon cancers. Furthermore, several observational studies have demonstrated the efficacy and dose-dependent and anti-cancer effects of exercise on decreasing the mortality and risk of recurrence before and after the colorectal cancer (CRC) diagnosis. However, the required exercise dose, type and intensity are yet unclear. The results of randomised prospective studies are expected to determine the optimal amount, type and intensity of exercise and formulate the most appropriate exercise plan and guidelines, according to the requirements and comorbidities of the patients. In addition, recent studies have focused on the molecular and genetic mechanisms underlying the effect of physical activity on disease outcomes and recurrence rates. This review aimed to investigate the effects of physical activity and the biological basis of these effects in preventing the risk and recurrence of CRC and decreasing the hazards of cancer and cancer treatment.

Keywords: Colorectal cancer; Exercise; Physical activity.

Figure 1

Biological potential pathways as explanatory mechanisms of the association between physical activity and primary and secondary prevention of colorectal cancer/potential biomarkers in secondary prevention. SPARC: Secretory protein acidic and rich in cysteine; PGC-1 α: Peroxisome proliferator-activated receptor gamma co-activator 1α; CTKN1B: Cyclin-dependent kinase inhibitor 1B; IRS1: İnsulin receptor substrate 1; CTNNB1: Catenin beta 1; PTGS2: Prostaglandin-endoperoxide synthase 2; COX-2: Cyclooxygenase-2; TNF- α: Tumor necrosıs factor alpha; iNOS: İnducible nitric oxide synthase.