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Review
. 1987 Jun:72:237-49.
doi: 10.1289/ehp.8772237.

Teratological research using in vitro systems. V. Nonmammalian model systems

Review

Teratological research using in vitro systems. V. Nonmammalian model systems

T F Collins. Environ Health Perspect. 1987 Jun.

Abstract

In this review of alternative tests to whole-animal rodent studies, the use of sub-mammalian and sub-vertebrate systems is investigated. The history, methodology, known limitations, end points, dose response, and requirements of virus, hydra, planarian, cricket, fish, amphibia, Drosophila, and chicken embryo systems are discussed.

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