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. 2019 May 28;11(6):1207.
doi: 10.3390/nu11061207.

High Relative Abundance of Lactobacillus reuteri and Fructose Intake are Associated with Adiposity and Cardiometabolic Risk Factors in Children from Mexico City

Eira E Huerta-Ávila  1 , Ivonne Ramírez-Silva  2 , Luisa E Torres-Sánchez  3 , Cinthya E Díaz-Benítez  4 , Yaneth C Orbe-Orihuela  5 , Alfredo Lagunas-Martínez  6 , Marcia Galván-Portillo  7 , Mario Flores  8 , Miguel Cruz  9 , Ana I Burguete-García  10
Affiliations

High Relative Abundance of Lactobacillus reuteri and Fructose Intake are Associated with Adiposity and Cardiometabolic Risk Factors in Children from Mexico City

Eira E Huerta-Ávila et al. Nutrients. .

Abstract

In Mexico, 3 of 10 children are overweight. Fructose intake and relative abundance (RA) of Lactobacillus reuteri (L. reuteri) in the intestinal microbiota are associated with obesity and diabetes in adults, but studies in children are limited. This study evaluates the association between fructose intake and L. reuteri RA with adiposity and cardiometabolic risk markers in Mexican children dietary information, microbiota profiles, adiposity indicators (Body Mass Index, BMI and Waste Circumference, WC), and cardiometabolic markers were analyzed in 1087 children aged 6-12 years. Linear regression and path analysis models were used. High-tertile fructose intake and L. reuteri RA were positively associated with BMI (βTertil 3 vs. Tertil 1 = 0.24 (95% CI, 0.04; 0.44) and βT3 vs. T1 = 0.52 (95% CI, 0.32; 0.72)) and WC (βT3 vs. T1 = 2.40 (95% CI, 0.93; 3.83) and βT3 vs. T1 = 3.40 (95% CI, 1.95; 4.90)), respectively. Also, these factors mediated by adiposity were positively correlated with high triglycerides and insulin concentrations and HOMA-IR (p ≤ 0.03) and negatively associated with HDL-C concentration (p < 0.01). High-tertile fructose intake and L. reuteri RA were directly associated with adiposity and indirectly associated though adiposity with metabolic disorders in children. In conclusion, fructose intake and L. reuteri RA were directly associated with adiposity and indirectly associated with metabolic disorders in children, mediated by adiposity.

Keywords: Lactobacillus reuteri; adiposity; cardiometabolic markers; children; cholesterol; fructose.

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Conflict of interest statement

Eira E. Huerta-Ávila, Ivonne Ramírez-Silva, Luisa E. Torres-Sánchez, Cinthya E. Díaz-Benítez, Yaneth C. Orbe-Orihuela, Alfredo Lagunas-Martínez, Marcia Galván-Portillo, Mario Flores, Miguel Cruz, and Ana I. Burguete have no conflicts of interest.

Figures

Figure 1
Figure 1
Children from México City study sample.
Figure 2
Figure 2
Main food and beverage that provide fructose to diet of children. (A) Show the percentage of contribution from main foods and beverage to the diet of school-aged children. (B) Show the percentage of contribution from main foods and beverage to the diet of school-aged children by weight status. One-way ANOVA with Bonferroni posttest. Marginally significant difference * p < 0.10. OW, overweight; OB, Obesity
See this image and copyright information in PMC

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