Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2019 May 29;19(1):30.
doi: 10.1186/s40644-019-0213-9.

Comparison of diffusion kurtosis imaging versus diffusion weighted imaging in predicting the recurrence of early stage single nodules of hepatocellular carcinoma treated by radiofrequency ablation

Zhen-Guo Yuan  1 , Zong-Ying Wang  2 , Meng-Ying Xia  1 , Feng-Zhi Li  2 , Yao Li  1 , Zhen Shen  2 , Xi-Zhen Wang  3
Affiliations
Comparative Study

Comparison of diffusion kurtosis imaging versus diffusion weighted imaging in predicting the recurrence of early stage single nodules of hepatocellular carcinoma treated by radiofrequency ablation

Zhen-Guo Yuan et al. Cancer Imaging. .

Abstract

Objective: This study aimed to compare the diffusion kurtosis imaging (DKI) versus diffusion weighted imaging (DWI) in predicting the recurrence of early stage single nodules of hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).

Materials and methods: A retrospective analysis of 107 patients with early stage single nodules of HCC was performed, all patients treated by RFA. Recurrence rate of HCC was recorded after a median follow-up of 36 months. During follow-up, the data of magnetic resonance imaging (MRI), DWI and DKI were obtained in multiple time points. The predictive values of DWI and DKI were analyzed using ROC curves.

Results: The overall recurrence rate was 66.3% (71/107). The sensitivity, specificity, and AUC for ADC, MD and MK after RFA (78.6, 73.3% and 0.842; 85.7, 83.3% and 0.839; 85.7, 96.7% and 0.956) were higher than before RFA (44.3, 53.3% and 0.560; 51.2, 56.7% and 0.543; 43.6, 67.3% and 0.489). The sensitivity, specificity, and AUC for MK after RFA were 85.7, 96.7%, and 0.956, respectively, which were significantly greater than those of ADC (78.6, 73.3% and 0.842; P < 0.05) and MD (85.7, 83.3% and 0.839).

Conclusions: The prediction efficacy of DKI for the recurrence of early stage single nodules of HCC was better than that of DWI. And, MK was the most sensitive predictor among the DKI.

Keywords: Diffusion kurtosis imaging; Diffusion weighted imaging; Hepatocellular carcinoma; Radiofrequency ablation.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no competing interests.

Figures

Fig. 1
Fig. 1
Follow-up flow chart
Fig. 2
Fig. 2
Images of a 48-year-old man with early stage single nodule of HCC. a axial fat-saturated T2WI image shows that the lesion of left hepatic lobe is slightly high signal intensity. b and c axial DWI and ADC map indicate that the diffusion of the lesion is obviously limited. d DCE arterial phase shows that the lesion has mild enhancement. e DKI-MD map shows that the MD value for the lesion is 1.181 × 10− 3. f DKI-MK map shows that the MK value for the lesion is 7.721 × 10− 1
Fig. 3
Fig. 3
(The same patient in Fig. 2, after treatment by RFA for one month) a axial T1WI and b axial fat-saturated T2WI indicate that the signal strength of the lesion is reduced compared with that before. c and d: axial DWI and ADC map show that the diffused degree of the lesion is obviously reduced. e DKI-MD map show that the MD value for the lesion is 1.300 × 10− 3. f DKI-MK map show that the MK value for the lesion is 5.906 × 10− 1
Fig. 4
Fig. 4
a The ADC, MD and MK of the recurrence groups and Non-recurrence groups before RFA (P>0.05). b The ADC, MD and MK of the recurrence groups and Non-recurrence groups after RFA (P<0.05). c The values of ADC, MD and MK before and after RFA (P < 0.05)
Fig. 5
Fig. 5
a: ROC curve of MK. b ROC curve of MD. c ROC curve of ADC
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. CA Cancer J Clin. 2016;66(2):115–132. doi: 10.3322/caac.21338. - DOI - PubMed
    1. Kim YS, Lim HK, Rhim H, Lee MW, Choi D, Lee WJ, et al. Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma: analysis of prognostic factors. J Hepatol. 2013;58(1):89–97. doi: 10.1016/j.jhep.2012.09.020. - DOI - PubMed
    1. Llovet JM, Ducreux M, Lencioni R, Di Bisceglie AM, Galle PR, Dufour JF, et al. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012;56(4):908–943. doi: 10.1016/j.jhep.2011.12.001. - DOI - PubMed
    1. Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Nakagawa H, et al. Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognosticfactors. Am J Gastroenterol. 2012;107(4):569–577. doi: 10.1038/ajg.2011.425. - DOI - PMC - PubMed
    1. Cui X, Wu Y, Wang Z, Liu X, Wang S, Qin C. MicroRNA-34a expression is predictive of recurrenceafter radiofrequency ablation in early hepatocellular carcinoma. Tumour Biol. 2015;36(5):3887–3893. doi: 10.1007/s13277-014-3031-5. - DOI - PubMed

Publication types