Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Aug;16(8):683-684.
doi: 10.1038/s41423-019-0240-2. Epub 2019 May 29.

Autophagy induced by STING, an unnoticed and primordial function of cGAS

Junjie Yang  1 , Xiaoshan Tang  1 , Kutty Selva Nandakumar  1 , Kui Cheng  2
Affiliations
Comment

Autophagy induced by STING, an unnoticed and primordial function of cGAS

Junjie Yang et al. Cell Mol Immunol. 2019 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Autophagy induced via cGAS-STING and its signaling pathway. a Exogenously or endogenously damaged dsDNA stimulates cGAS to produce cGAMP. cGAMP binds to STING, and the cGAMP-STING complex recruits SAR1 and SEC24C to form the COP-ll complex. The COP-ll complex translocates from the ER to ERGIC. b The ERGIC serves as a membrane source for LC3 lipidation, which is dependent on WIPI2. LC3-positive membranes enclose dsDNA, bacteria or viruses and form autophagosomes. c The autophagosome transferred to the lysosome is digested by various enzymes
See this image and copyright information in PMC

Comment on

References

    1. Gui X, et al. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature. 2019;567:262–266. doi: 10.1038/s41586-019-1006-9. - DOI - PMC - PubMed
    1. Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat. Rev. Mol. Cell Biol. 2018;19:349–364. doi: 10.1038/s41580-018-0003-4. - DOI - PubMed
    1. Denton D, Kumar S. Autophagy-dependent cell death. Cell Death Differ. 2019;26:606–616. - PMC - PubMed
    1. Ablasser A, Chen ZJ. cGAS in action: expanding roles in immunity and inflammation. Science. 2019;363:eaat8657. doi: 10.1126/science.aat8657. - DOI - PubMed
    1. Liang G, Melville D, Zhang M, Schekman R. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. elife. 2013;2:e00947. doi: 10.7554/eLife.00947. - DOI - PMC - PubMed

Publication types

Substances