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. 2019 Mar;8(Suppl 1):S22-S30.
doi: 10.21037/tau.2018.12.13.

Impact of advanced paternal age on the intracytoplasmic sperm injection (ICSI) outcomes in donor egg cycles

Gianmartin Cito  1 , Maria Elisabetta Coccia  2 , Rita Picone  2 , Andrea Cocci  1 , Giorgio Ivan Russo  3 , Giulio Garaffa  4 , Rossella Fucci  2 , Francesco Bertocci  2 , Elena Borrani  2 , Valentina Basile  2 , Elisabetta Micelli  5 , Luciana Criscuoli  2 , Sergio Serni  1 , Marco Carini  1 , Alessandro Natali  1
Affiliations

Impact of advanced paternal age on the intracytoplasmic sperm injection (ICSI) outcomes in donor egg cycles

Gianmartin Cito et al. Transl Androl Urol. 2019 Mar.

Abstract

Background: The purpose of this study is to assess the impact of paternal age on the oocyte-donation outcomes in intracytoplasmic sperm injection (ICSI) cycles.

Methods: Two hundred and seventy-eight infertile couples were retrospectively involved. Inclusion criteria were: infertility from almost 1 year, normal or sub-fertile seminal parameters, overall oocyte survival rate greater than 85%. Baseline characteristics included male age, recipient age, male body mass index (BMI), smoking, drinking status. Main outcome measures: fertilization rate (FR), cleavage rate (CR), pregnancy rate (PR).

Results: Patients were categorized in group 1 ≤45, group 2 >45 years. A total of 1,724 frozen oocytes were included. After warming, 1,642 oocytes survived. Median overall oocyte survival rate was 100% [interquartile range (IQR), 85-100%]. Median male age was 44±5.60 years (IQR, 31-70 years). Median recipients age was 42±3.62 years (IQR, 29-50 years). Group 1 included 166 men, group 2 112 men. Two hundred and seventy-eight fresh ICSI cycle were performed. "Two-pronuclear" (2PN) FR was 72.6%±0.20%, CR 93.0%±0.16%, PR 39.6%. Miscarriage rate was 25.5%. Live birth rate per cycles was 29.5%. Comparison between group 1, group 2 and ICSI outcomes confirmed an association with FR, resulting 80.0% (IQR, 67.0-83.0%) and 67.0% (IQR, 50.0-80.0%), respectively (P<0.01). There were no significant differences between the two groups with respect to seminal parameters.

Conclusions: It would be recommended more emphasis on the advancing male age when counselling older couples who undergo egg donation program.

Keywords: Aging male; infertility; intracytoplasmic sperm injection (ICSI).

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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