Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention

doi:10.1007/s11764-019-00768-8

. 2019 Jun;13(3):468-476.

doi: 10.1007/s11764-019-00768-8. Epub 2019 May 29.

Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention

Lauren S Weiner^{1

2}, Michelle Takemoto¹, Suneeta Godbole¹, Sandahl H Nelson^{1

2}, Loki Natarajan^{1

2}, Dorothy D Sears^{1

2

3

4}, Sheri J Hartman^{5

6}

Affiliations

¹ Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, San Diego, CA, USA.
² UC San Diego Moores Cancer Center, University of California, San Diego, La Jolla, San Diego, CA, USA.
³ Department of Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.
⁴ College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
⁵ Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, San Diego, CA, USA. sjhartman@ucsd.edu.
⁶ UC San Diego Moores Cancer Center, University of California, San Diego, La Jolla, San Diego, CA, USA. sjhartman@ucsd.edu.

PMID: 31144265
PMCID: PMC6791122
DOI: 10.1007/s11764-019-00768-8

Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention

Lauren S Weiner et al. J Cancer Surviv. 2019 Jun.

. 2019 Jun;13(3):468-476.

doi: 10.1007/s11764-019-00768-8. Epub 2019 May 29.

Authors

Lauren S Weiner^{1

2}, Michelle Takemoto¹, Suneeta Godbole¹, Sandahl H Nelson^{1

2}, Loki Natarajan^{1

2}, Dorothy D Sears^{1

2

3

4}, Sheri J Hartman^{5

6}

Affiliations

¹ Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, San Diego, CA, USA.
² UC San Diego Moores Cancer Center, University of California, San Diego, La Jolla, San Diego, CA, USA.
³ Department of Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.
⁴ College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
⁵ Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, San Diego, CA, USA. sjhartman@ucsd.edu.
⁶ UC San Diego Moores Cancer Center, University of California, San Diego, La Jolla, San Diego, CA, USA. sjhartman@ucsd.edu.

PMID: 31144265
PMCID: PMC6791122
DOI: 10.1007/s11764-019-00768-8

Abstract

Purpose: Cancer survivors are highly sedentary and have low physical activity. How physical activity interventions impact sedentary behavior remains unclear. This secondary analysis examined changes in sedentary behavior among breast cancer survivors participating in a physical activity intervention that significantly increased moderate-to-vigorous physical activity (MVPA).

Methods: Insufficiently active breast cancer survivors were randomized to a 12-week physical activity intervention (exercise arm) or control arm. The intervention focused solely on increasing MVPA with no content targeting sedentary behavior. Total sedentary behavior, light physical activity (LPA), and MVPA were measured at baseline and 12 weeks (ActiGraph GT3X+ accelerometer). Separate linear mixed-effects models tested intervention effects on sedentary behavior, intervention effects on LPA, the relationship between change in MVPA and change in sedentary behavior, and potential moderators of intervention effects on sedentary behavior.

Results: The exercise arm had significantly greater reductions in sedentary behavior than the control arm (mean - 24.9 min/day (SD = 5.9) vs. - 4.8 min/day (SD = 5.9), b = - 20.1 (SE = 8.4), p = 0.02). Larger increases in MVPA were associated with larger decreases in sedentary behavior (b = - 1.9 (SE = 0.21), p < 0.001). Women farther out from surgery had significantly greater reductions in sedentary behavior than women closer to surgery (b = - 0.91 (SE = 0.5), p = 0.07). There was no significant group difference in change in LPA from baseline to 12 weeks (b = 5.64 (SE = 7.69), p = 0.48).

Conclusions: Breast cancer survivors in a physical activity intervention reduced total sedentary time in addition to increasing MVPA.

Implications for cancer survivors: Both increasing physical activity and reducing sedentary behavior are needed to promote optimal health in cancer survivors. These results show that MVPA and sedentary behavior could be successfully targeted together, particularly among longer-term cancer survivors.

Clinical trial registration: This study is registered at www.ClinicalTrials.gov (NCT02332876).

Keywords: Breast cancer; Physical activity; Sedentary behavior; Sitting.

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Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

Figures

**Fig. 1**
Change in sedentary time (minutes per day) between baseline and 12 weeks for someone 12 months vs. 36 months since surgery, by study arm (N = 87)

See this image and copyright information in PMC

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References

1. Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–89. - PubMed
1. Sabiston CM, Brunet J, Vallance JK, Meterissian S. Prospective examiniation of objectively-assessed physical activity and sedentary time after breast cancer treatment: sitting on the crest of the teachable moment. Cancer Epidemiol Biomark Prev. 2014;23(7): 1324–30. - PubMed
1. Lynch BM, Dunstan DW, Healy GN, Winkler E, Eakin E, Owen N. Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003–2006). Cancer Causes Control. 2010;21(2):283–8. - PubMed
1. Phillips SM, Awick EA, Conroy DE, Pellegrini CA, Mailey EL, McAuley E. Objectively measured physical activity and sedentary behavior and quality of life indicators in survivors of breast cancer. Cancer. 2015;121(22):4044–52. - PMC - PubMed
1. Gennuso KP, et al. Sedentary behavior, physical activity, and markers of health in older adults. Med Sci Sports Exerc. 2013;45(8):1493–500. - PMC - PubMed

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[1] Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–89. - PubMed

[2] Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–89. - PubMed

[3] Sabiston CM, Brunet J, Vallance JK, Meterissian S. Prospective examiniation of objectively-assessed physical activity and sedentary time after breast cancer treatment: sitting on the crest of the teachable moment. Cancer Epidemiol Biomark Prev. 2014;23(7): 1324–30. - PubMed

[4] Sabiston CM, Brunet J, Vallance JK, Meterissian S. Prospective examiniation of objectively-assessed physical activity and sedentary time after breast cancer treatment: sitting on the crest of the teachable moment. Cancer Epidemiol Biomark Prev. 2014;23(7): 1324–30. - PubMed

[5] Lynch BM, Dunstan DW, Healy GN, Winkler E, Eakin E, Owen N. Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003–2006). Cancer Causes Control. 2010;21(2):283–8. - PubMed

[6] Lynch BM, Dunstan DW, Healy GN, Winkler E, Eakin E, Owen N. Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003–2006). Cancer Causes Control. 2010;21(2):283–8. - PubMed

[7] Phillips SM, Awick EA, Conroy DE, Pellegrini CA, Mailey EL, McAuley E. Objectively measured physical activity and sedentary behavior and quality of life indicators in survivors of breast cancer. Cancer. 2015;121(22):4044–52. - PMC - PubMed

[8] Phillips SM, Awick EA, Conroy DE, Pellegrini CA, Mailey EL, McAuley E. Objectively measured physical activity and sedentary behavior and quality of life indicators in survivors of breast cancer. Cancer. 2015;121(22):4044–52. - PMC - PubMed

[9] Gennuso KP, et al. Sedentary behavior, physical activity, and markers of health in older adults. Med Sci Sports Exerc. 2013;45(8):1493–500. - PMC - PubMed

[10] Gennuso KP, et al. Sedentary behavior, physical activity, and markers of health in older adults. Med Sci Sports Exerc. 2013;45(8):1493–500. - PMC - PubMed

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Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention

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Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention

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