Tumor-associated macrophages: role in cancer development and therapeutic implications

Arash Salmaninejad^{1

2}, Saeed Farajzadeh Valilou³, Arash Soltani^{2

4}, Sepideh Ahmadi^{5

6}, Yousef Jafari Abarghan², Rhonda J Rosengren⁷, Amirhossein Sahebkar^{8

9

10

11}

Affiliations

¹ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Medical Genetics Research Center, Student Research Committee, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁴ Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁷ Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
⁸ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
⁹ Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
¹⁰ School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
¹¹ Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. box: 91779-48564, Mashhad, Iran. sahebkara@mums.ac.ir.

PMID: 31144271
DOI: 10.1007/s13402-019-00453-z

Review

Tumor-associated macrophages: role in cancer development and therapeutic implications

Arash Salmaninejad et al. Cell Oncol (Dordr). 2019 Oct.

. 2019 Oct;42(5):591-608.

doi: 10.1007/s13402-019-00453-z. Epub 2019 May 29.

Authors

Arash Salmaninejad^{1

2}, Saeed Farajzadeh Valilou³, Arash Soltani^{2

4}, Sepideh Ahmadi^{5

6}, Yousef Jafari Abarghan², Rhonda J Rosengren⁷, Amirhossein Sahebkar^{8

9

10

11}

Affiliations

¹ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Medical Genetics Research Center, Student Research Committee, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁴ Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁷ Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
⁸ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
⁹ Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
¹⁰ School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
¹¹ Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. box: 91779-48564, Mashhad, Iran. sahebkara@mums.ac.ir.

PMID: 31144271
DOI: 10.1007/s13402-019-00453-z

Abstract

Background: Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer. In this review, the signaling pathways, origin, function, polarization and clinical application of TAMs are discussed. The role of TAMs in tumor initiation, progression, angiogenesis, invasion and metastasis are also emphasized. In addition, a variety of clinical and pre-clinical approaches to target TAMs are discussed.

Conclusions: Clinical therapeutic approaches that show most promise include blocking the extravasation of TAMs along with using TAMs as diagnostic biomarkers for cancer progression. The targeting of TAMs in a variety of clinical settings appears to be a promising strategy for decreasing metastasis formation and for improving patient outcome.

Keywords: Angiogenesis; Cancer; Immunotherapy; Macrophage; Metastasis; TAM; Targeted therapy.

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References

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Tumor-associated macrophages: role in cancer development and therapeutic implications

Affiliations

Tumor-associated macrophages: role in cancer development and therapeutic implications

Authors

Affiliations

Abstract

References

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LinkOut - more resources

Full Text Sources